Publication Archive

2011

Adelson PD, Srinivas R, Chang Y, Bell M, Kochanek PM. Cerebrovascular response in children following severe traumatic brain injury. Childs Nerv Syst. 2011 Sep; 27(9):1465-76.

Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499.

Au AK, Carcillo JA, Clark RS, Bell MJ: Brain injuries and neurological system failure are the most common proximate causes of death in children admitted to a pediatric intensive care unit. Pediatr Crit Care Med. 2011 Sep;12(5):566-71.

Bales JW, Yan HQ, Ma X, Li Y, Samarasinghe R, Dixon CE: The dopamine and cAMP regulated phosphoprotein, 32kDa (DARPP-32) signaling pathway: A novel therapeutic target in traumatic brain injury. Exp Neurol. 2011  Jun;(2):300-7.

Baltagi S, Fink EL, Bell MJ. Therapeutic hypothermia: Ready ... fire ... aim? How small feasibility studies can inform large efficacy trials. Pediatr Crit Care Med. 2011 May;12(3):370-1.

Becker LB, Aufderheide TP, Geocadin RG, Callaway CW, Lazar RM, Donnino MW, Nadkarni VM, Abella BS, Adrie C, Berg RA, Merchant RM, O'Connor RE, Meltzer DO, Holm MB, Longstreth WT, Halperin HR; American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association. Circulation. 2011 Nov 8;124(19):2158-77.

Belikova NA, Glumac AL, Kapralova V, Cheikhi A, Tyurina YY, Vagni VA, Kochanek PM, Kagan VE, Bayir H.  A high-throughput screening assay of ascorbate in brain samples.  J Neurosci Methods. 2011 Sep 30;201(1):185-90.

Berger RP.  Predicting outcome after severe pediatric traumatic brain injury: making progress one baby step at a time.  Pediatr Crit Care Med. 2011 May;12(3):362-4.

Berger RP, Fromkin JB, Stutz H, Makoroff K, Scribano PV, Feldman K, Tu LC, Fabio A.  Abusive Head Trauma During a Time of Increased Unemployment: A Multicenter Analysis.  Pediatrics. 2011 Oct;128(4):637-43.

Berger RP, Houle JF, Hayes RL, Wang KK, Mondello S, Bell MJ. Translating biomarkers research to clinical care: applications and issues for rehabilomics. PM R. 2011 Jun;3(6 Suppl):S31-8.

Bulger EM, May S, Kerby JD, Emerson S, Stiell IG, Schreiber MA, Brasel KJ, Tisherman SA, Coimbra R, Rizoli S, Minei JP, Hata JS, Sopko G, Evans DC, Hoyt DB: Out-of-hospital Hypertonic Resuscitation After Traumatic Hypovolemic Shock: A Randomized, Placebo Controlled Trial. Ann Surg. 2011 Mar;253(3):431-441.

Callaway CW: Refining the use of therapeutic hypothermia after cardiac arrest. Crit Care Med. 2011 Jan;39(1):201-2.

Darrah SH, Chuang J, Mohler LM, Chen X, Cummings EE, Burnett T, Reyes-Littaua MC, Galang GN, Wagner AK: Dilantin Therapy in an Experimental Model of Traumatic Brain Injury: Effects of Limited versus Daily Treatment on Neurological and Behavioral Recovery. J Neurotrauma. 2011 Jan;28(1):43-55.

de Witt BW, Ehrenberg KM, McAloon RL, Panos AH, Shaw KE, Raghavan PV, Skidmore ER, Kline AE: Abbreviated Environmental Enrichment Enhances Neurobehavioral Recovery Comparably to Continuous Exposure After Traumatic Brain Injury. Neurorehabil Neural Repair. 2011 May;25(4):343-50.

Drabek T, Kochanek PM, Stezoski J, Wu X, Bayir H, Morhard RC, Stezoski SW, Tisherman SA: Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. Shock. 2011 Jan;35(1):67-73.

Duffy SO, Squires J, Fromkin JB, Berger RP: Use of skeletal surveys to evaluate for physical abuse: analysis of 703 consecutive skeletal surveys. Pediatrics. 2011 Jan;127(1):e47-52.

Exo J, Kochanek PM, Adelson PD, Greene S, Clark RS, Bayir H, Wisniewski SR, Bell MJ: Intracranial pressure-monitoring systems in children with traumatic brain injury: Combining therapeutic and diagnostic tools. Pediatr Crit Care Med. 2011 Sep;12(5):560-5.

Garcia AN, Shah MA, Dixon CE, Wagner AK, Kline AE. Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation. PM R. 2011 Jun;3(6 Suppl):S18-27.

Garman RH, Jenkins LW, Switzer Iii RC, Bauman RA, Tong LC, Swauger PV, Parks S, Ritzel DV, Dixon CE, Clark R, Bayir H, Kagan V, Jackson E, Kochanek PM: Blast exposure in rats with body shielding is characterized by diffuse axonal injury. J Neurotrauma. 2011 Jun; 28(6):947-59.

Joffe AR, Carcillo J, Anton N, Decaen A, Han YY, Bell MJ, Maffei FA, Sullivan J, Thomas J, Garcia-Guerra G. Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent. Philos Ethics Humanit Med. 2011 Dec 29;6(1):17.

Kochanek PM. Mass critical care for children: implications for adult critical care. Crit Care Med. 2011 Dec;39(12):2783.

Kochanek PM, Bramlett H, Dietrich WD, Dixon CE, Hayes RL, Povlishock J, Tortella FC, Wang KK.  A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.    J Trauma. 2011 Jul;71(1 Suppl):S15-24.

Kochanek PM, Kissoon N: Pediatric Critical Care Medicine: Re-tooling to accommodate growth and success while preserving excellence. Pediatr Crit Care Med. 2011 Jan;12(1):1.

Manole MD, Kochanek PM, Clark RS.  "Lost in translation?" Noninvasive cerebral monitoring after cardiac arrest.  Crit Care Med. 2011 Oct;39(10):2379-80.

Manole MD, Tehranian-Depasquale R, Du L, Bayır H, Kochanek PM, Clark RS.  Unmasking Sex-Based Disparity in Neuronal Metabolism.  Curr Pharm Des. 2011 17:3854-3860.]

Martin-Gill C, Dilger CP, Guyette FX, Rittenberger JC, Callaway CW. Regional Impact of Cardiac Arrest Center Criteria on Out-of-Hospital Transportation Practices. Prehosp Emerg Care. 2011  Jul-Sep;15(3):381-7.

Matter AM, Folweiler KA, Curatolo LM, Kline AE: Temporal Effects of Environmental Enrichment-Mediated Functional Improvement After Experimental Traumatic Brain Injury in Rats. Neurorehabil Neural Repair. 2011 Jul;25(6):558-64.

Metter RB, Rittenberger JC, Guyette FX, Callaway CW. Association between a quantitative CT scan measure of brain edema and outcome after cardiac arrest. Resuscitation. 2011 Sep;82(9):1180-5.

Moler FW, Donaldson AE, Meert K, Brilli RJ, Nadkarni V, Shaffner DH, Schleien CL, Clark RS, Dalton HJ, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Pineda J, Hernan L, Dean JM; Pediatric Emergency Care Applied Research Network: Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med. 2011 Jan;39(1):141-9.

Morley J, Beauchamp G, Suyama J, Guyette FX, Reis SE, Callaway CW, Hostler D. Cognitive function following treadmill exercise in thermal protective clothing. Eur J Appl Physiol. 2011 Sep 3. [Epub ahead of print]

Reinier K, Thomas E, Andrusiek DL, Aufderheide TP, Brooks SC, Callaway CW, Pepe PE, Rea TD, Schmicker RH, Vaillancourt C, Chugh SS. Socioeconomic status and incidence of sudden cardiac arrest. CMAJ. 2011 Oct 18;183(15):1705-12

Rittenberger JC, Callaway CW. Muddy Waters: Hypothermia Does Not Work? Resuscitation. 2011 Sep;82(9):1120-1.

Rittenberger JC, Raina K, Holm MB, Kim YJ, Callaway CW. Association between Cerebral Performance Category, Modified Rankin Scale, and discharge disposition after cardiac arrest. Resuscitation. 2011 Aug;82(8):1036-40.

Rittenberger JC, Tisherman SA, Holm MB, Guyette FX, Callaway CW.  An early, novel illness severity score to predict outcome after cardiac arrest.  Resuscitation. 2011 Nov;82(11):1399-404.

Shellington DK, Du L, Wu X, Exo J, Vagni V, Ma L, Janesko-Feldman K, Clark RS, Bayir H, Dixon CE, Jenkins LW, Hsia CJ, Kochanek PM: Polynitroxylated pegylated hemoglobin: A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice Crit Care Med. 2011 Mar;39(3):494-505.

Shin SS, Bray ER, Zhang CQ, Dixon CE: Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats. Brain Res. 2011 Jan 19;1369:208-15.

Shin SS, Dixon CE. Oral fish oil restores striatal dopamine release after traumatic brain injury. Neurosci Lett. 2011 Jun 8;496(3):168-71.

Singbartl K, Murugan R, Kaynar AM, Crippen DW, Tisherman SA, Shutterly K, Stuart SA, Simmons R, Darby JM. Intensivist-Led Management of Brain-Dead Donors Is Associated with an Increase in Organ Recovery for Transplantation. Am J Transplant. 2011 Jul;11(7):1517-21.

Smith CM, Adelson PD, Chang YF, Brown SD, Kochanek PM, Clark RS, Bayir H, Hinchberger J, Bell MJ: Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury. Pediatr Crit Care Med. 2011 Jul;12(4):449-54.

Smith CM, Chen Y, Sullivan ML, Kochanek PM, Clark RS: Autophagy in Acute Brain Injury: Feast, Famine, or Folly? Neurobiol Dis.  2011 Jul;43(1):52-9.

Stoyanovsky DA, Huang Z, Jiang J, Belikova NA, Tyurin V, Epperly MW, Greenberger JS, Bayir H, Kagan VE.  A manganese-porphyrin complex decomposes H(2)O(2), inhibits apoptosis, and acts as a radiation mitigator in vivo.  ACS Med Chem Lett. 2011 Nov 10;2(11):814-817.

Suffoletto B, Frisch A, Prabhu A, Kristan J, Guyette FX, Callaway CW. Prediction of Serious Infection during Prehospital Emergency Care. Prehosp Emerg Care. 2011  Jul-Sep;15(3):325-30.

Tisherman SA, Ivy ME, Frangos SG, Kirton OC: Acute care surgery survey: opinions of surgeons about a new training paradigm. Arch Surg. 2011 Jan;146(1):101-6.

Verrier JD, Exo JL, Jackson TC, Ren J, Gillespie DG, Dubey RK, Kochanek PM, Jackson EK. Expression of the 2',3'-cAMP-adenosine pathway in astrocytes and microglia.  J Neurochem. 2011 Sep;118(6):979-87.

Wagner AK. Conclusions on biologics in rehabilitation research and clinical care. PM R. 2011 Jun;3(6 Suppl):S158.

Wagner AK. Rehabilomics: a conceptual framework to drive biologics research. PM R. 2011 Jun;3(6 Suppl):S28-30.

Wagner AK, Amin KB, Niyonkuru C, Postal BA, McCullough EH, Ozawa H, Dixon CE, Bayir H, Clark RS, Kochanek PM, Fabio A: CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI. J Cereb Blood Flow Metab. 2011 Sep;31(9):1886-96.

Wagner AK, McCullough EH, Niyonkuru C, Ozawa H, Loucks TL, Dobos JA, Brett CA, Santarsieri M, Dixon CE, Berga SL, Fabio A. Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury. J Neurotrauma. 2011 Jun;28(6):871-88.

2010

Abdulkadir AA, Kimimasa T, Bell MJ, Macpherson TA, Keller BB, Yanowitz TD: Placental Inflammation and Fetal Hemodynamics in a Rat Model of Chorioamnionitis. Pediatr Res. 2010 Dec;68(6):513-8.

Au AK, Bayir H, Kochanek PM, Clark RS: Evaluation of autophagy using mouse models of brain injury. Biochim Biophys Acta. 2010 Oct;1802(10):918-23

Au A, Bell MJ: Prevention of hospital-acquired hyponatremia in children: Are hypotonic solutions safe? Pediatr Crit Care Med. 2010 Jul;11(4):528-9

Bales JW, Ma X, Yan HQ, Jenkins LW, Dixon CE: Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Brain Res. 2010 Oct 28;1358:211-20

Bales JW, Ma X, Yan HQ, Jenkins LW, Dixon CE:  Expression of protein phosphatase 2B (calcineurinsubunit A isoforms in rat hippocampus after traumatic brain injury.  J Neurotrauma. 2010 Jan;27(1):109-20

Baltagi SA, Shoykhet M, Felmet K, Kochanek PM, Bell MJ:  Neurological sequelae of pH1N1 influenza in children: A case series observed during a pandemic*.  Pediatr Crit Care Med. 2010 Mar;11(2):179-84

Berger RP, Bazaco MC, Wagner AK, Kochanek PM, Fabio A: Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury. Dev Neurosci. 2010;32(5-6):396-405

Bonneh-Barkay D, Zagadailov P, Zou H, Niyonkuru C, Figley M, Starkey A, Wang G, Bissel SJ, Wiley CA, Wagner AK: YKL-40 Expression in Traumatic Brain Injury: An Initial Analysis. J Neurotrauma. 2010 Jul 12.Jul;27(7):1215-23.

Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, Newgard C, Slutsky A, Coimbra R, Emerson S, Minei JP, Bardarson B, Kudenchuk P, Baker A, Christenson J, Idris A, Davis D, Fabian TC, Aufderheide TP, Callaway C, Williams C, Banek J, Vaillancourt C, van Heest R, Sopko G, Hata JS, Hoyt DB; ROC Investigators: Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial. JAMA. 2010 Oct 6;304(13):1455-64.

Callaway CW, Schmicker R, Kampmeyer M, Powell J, Rea TD, Daya MR, Aufderheide TP, Davis DP, Rittenberger JC, Idris AH, Nichol G; The Resuscitation Outcomes Consortium (ROC) Investigators:  Receiving hospital characteristics associated with survival after out-of-hospital cardiac arrest.  Resuscitation. 2010 May;81(5):524-9.

D'Onofrio G, Jauch E, Jagoda A, Allen MH, Anglin D, Barsan WG, Berger RP, Bobrow BJ, Boudreaux ED, Bushnell C, Chan YF, Currier G, Eggly S, Ichord R, Larkin GL, Laskowitz D, Neumar RW, Newman-Toker DE, Quinn J, Shear K, Todd KH, Zatzick D; Roundtable External Participants and Roundtable Steering Committee and Federal Participants: NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies. Ann Emerg Med. 2010 Nov;56(5):551-64

Fink EL, Clark RS, Kochanek PM, Bell MJ, Watson RS:  A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest*.  Pediatr Crit Care Med. 2010 Jan;11(1):66-74.

Fink EL, Kochanek PM, Clark RS, Bell MJ:  How I Cool Children in Neurocritical Care. Neurocrit Care. 2010 Jun;12(3):414-20..

Hartke A, Mumma BE, Rittenberger JC, Callaway CW, Guyette FX: Incidence of re-arrest and critical events during prolonged transport of post-cardiac arrest patients. Resuscitation. 2010 Aug;81(8):938-42

Haselkorn ML, Shellington D, Jackson E, Vagni VA, Janesko KL, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM:  Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice. J Neurotrauma. 2010 May;27(5):901-10.

Hoh NZ, Wagner AK, Alexander SA, Clark RB, Beers SR, Okonkwo DO, Ren D, Conley YP: BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. J Neurotrauma. 2010 Aug;27(8):1413-27

Hostler D, Thomas EG, Emerson SS, Christenson J, Stiell IG, Rittenberger JC, Gorman KR, Bigham BL, Callaway CW, Vilke GM, Beaudoin T, Cheskes S, Craig A, Davis DP, Reed A, Idris A, Nichol G; Resuscitation Outcomes Consortium Investigators: Increased survival after EMS witnessed cardiac arrest. Observations from the Resuscitation Outcomes Consortium (ROC) Epistry-Cardiac arrest. Resuscitation. 2010 Jul;81(7):826-30.

Hostler D, Zhou J, Tortorici MA, Bies RR, Rittenberger JC, Empey PE, Kochanek PM, Callaway CW, Poloyac SM:  Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers.Drug Metab Dispos. 2010 May;38(5):781-8.

Janata A, Weihs W, Schratter A, Bayegan K, Holzer M, Frossard M, Sipos W, Springler G, Schmidt P, Sterz F, Losert UM, Laggner AN, Kochanek PM, Behringer W: Cold aortic flush and chest compressions enable good neurologic outcome after 15 minutes of ventricular fibrillation in cardiac arrest in pigs. Crit Care Med. 2010 Aug;38(8):1637-43.

King C, Robinson T, Dixon CE, Rao GR, Larnard DJ, Nemoto EM: Brain Temperature Profiles during Epidural Cooling with the Chillerpad in a Monkey Model of Traumatic Brain Injury. J Neurotrauma. 2010 Oct;27(10):1895-903.

Kline AE, McAloon RL, Henderson KA, Bansal UK, Ganti BM, Ahmed RH, Gibbs RB, Sozda CN: Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury. J Neurotrauma. 2010 Nov;27(11):2021-32

Kochanek PM, Bayir H: Titrating oxygen during and after cardiopulmonary resuscitation. JAMA. 2010 Jun 2;303(21):2190-1.

Kochanek PM, Bell MJ, Bayır H. Quo vadis 2010? - carpe diem: challenges and opportunities in pediatric traumatic brain injury. Dev Neurosci. 2010;32(5-6):335-342.

Mehta A, Kochanek PM, Tyler-Kabara E, Adelson PD, Wisniewski SR, Berger RP, Sidoni MD, Bell RL, Clark RS, Bell MJ: Relationship of intracranial pressure and cerebral perfusion pressure with outcome in young children after severe traumatic brain injury. Dev Neurosci. 2010;32(5-6):413-9

Miller MA, Conley Y, Scanlon JM, Ren D, Ilyas Kamboh M, Niyonkuru C, Wagner AK: APOE genetic associations with seizure development after severe traumatic brain injury. Brain Inj. 2010;24(12):1468-77

Nichol G, Aufderheide TP, Eigel B, Neumar RW, Lurie KG, Bufalino VJ, Callaway CW, Menon V, Bass RR, Abella BS, Sayre M, Dougherty CM, Racht EM, Kleinman ME, O'Connor RE, Reilly JP, Ossmann EW, Peterson E; on behalf of the American Heart Association Emergency Cardiovascular Care Committee; Council on Arteriosclerosis, Thrombosis, and Vascular Biology; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular Nursi:  Regional Systems of Care for Out-of-Hospital Cardiac Arrest. A Policy Statement From the American Heart Association.  Circulation. 2010 Feb 9;121(5):709-729.

Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Bbttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Vanden Hoek T; International Liaison Committee on Resuscitation; Emergency Cardiovascular Care Committee, American Heart Association; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiopulmonary, Perioperative, and Critical Care; Council on Clinical Cardiology; Council on Stroke: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication: a scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke (Part II). Int Emerg Nurs. 2010 Jan;18(1):8-28.

Ochalski PG, Fellows-Mayle W, Hsieh LB, Srinivas R, Okonkwo DO, Dixon CE, Adelson PD:  Flumazenil administration attenuates cognitive impairment in immature rats following controlled cortical impact.  J Neurotrauma. 2010 March:27(3): 647-651.

Rittenberger JC, Sangl J, Wheeler M, Guyette FX, Callaway CW: Association between clinical examination and outcome after cardiac arrest. Resuscitation. 2010 Sep;81(9):1128-1132.

Salcido DD, Stephenson AM, Condle JP, Callaway CW, Menegazzi JJ: Incidence of rearrest after return of spontaneous circulation in out-of-hospital cardiac arrest. Prehosp Emerg Care. 2010 Oct-Dec;14(4):413-8.

Salonia R, Empey P, Poloyac SM, Wisniewski SR, Klamerus M, Ozawa H, Wagner AK, Ruppel R, Bell MJ, Janesko KL, Adelson PD, Clark R, Kochanek PM: Endothelin-1 is Increased in Cerebrospinal Fluid and Associated with Unfavorable Outcomes in Children after Severe Traumatic Brain Injury. J Neurotrauma. 2010 Oct;27(10):1819-25.

Sanchez de Toledo J, Bell MJ: Complications of hypothermia: interpreting 'serious,' 'adverse,' and 'events' in clinical trials. Pediatr Crit Care Med. 2010 May;11(3):439-41

Sarnaik A, Conley YP, Okonkwo DO, Barr T, Fink EL, Szabo C, Kochanek PM, Clark R:  Influence of PARP-1 Polymorphisms in Patients after Traumatic Brain Injury.  J Neurotrauma. 2010 March:27(3):465-471

Singleton RH, Yan HQ, Fellows-Mayle W, Dixon CE: Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury. J Neurotrauma. 2010 Jun;27(6):1091-9.

Sozda CN, Hoffman AN, Olsen AS, Cheng JP, Zafonte R, Kline AE:  Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury.J Neurotrauma. 2010 Jun;27(6):1047-57.

Sparvero LJ, Amoscato AA, Kochanek PM, Pitt BR, Kagan VE, Bayir H: Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury. J Neurochem. 2010 Dec;115(6):1322-36

Stoyanovsky DA, Kapralov A, Huang Z, Maeda A, Osipov A, Hsia CJ, Ma L, Kochanek PM, Bayr H, Kagan VE: Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides. Biochem Biophys Res Commun. 2010 Aug 20;399(2):139-143.

Su E, Bell MJ, Wisniewski SR, Adelson PD, Janesko-Feldman KL, Salonia R, Clark RS, Kochanek PM, Kagan VE, Bayır H: α-Synuclein Levels Are Elevated in Cerebrospinal Fluid following Traumatic Brain Injury in Infants and Children: The Effect of Therapeutic Hypothermia. Dev Neurosci. 2010;32(5-6):385-95

Su E, Shoykhet M, Bell MJ: Severe hypernatremia in a hospitalized child: munchausen by proxy. Pediatr Neurol. 2010 Oct;43(4):270-3.

Tang M, Alexander H, Clark RS, Kochanek PM, Kagan VE, Bayır H:  Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest.  J Cereb Blood Flow Metab. 2010 Jan;30(1):119-29

Tisherman SA: Cannabinoids after cardiac arrest: should your brain be on drugs? Crit Care Med. 2010 Dec;38(12):2409-10

Tisherman SA: Is fibrinogen the answer to coagulopathy after massive transfusions? Crit Care. 2010 2010;14(3):154

Tisherman SA: The yin and yang of hypothermia in trauma. J Intensive Care Med. 2010 Jul;25(4):240-2.

Tisherman SA: When it comes to hypothermia and trauma: kids are really little adults. Pediatr Crit Care Med. 2010 Mar;11(2):301-2

Tisherman SA, Drabek T: Can an ice cream headache save your life? Crit Care Med. 2010 Mar;38(3):1006-7.

Tress EE, Kochanek PM, Saladino RA, Manole MD: Cardiac arrest in children. J Emerg Trauma Shock. 2010 Jul;3(3):267-72.

Tyurin VA, Tyurina YY, Ritov VB, Lysytsya A, Amoscato AA, Kochanek PM, Hamilton R, Dekosky ST, Greenberger JS, Bayir H, Kagan VE:  Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues.  Methods Mol Biol. 2010;610:353-74

Vitale MA, Squires J, Zuckerbraun NS, Berger RP:  Evaluation of the Siblings of Physically Abused Children: A Comparison of Child Protective Services Caseworkers and Child Abuse Physicians.Child Maltreat. 2010 May;15(2):144-51.

Wagner AK: The Traumatic Brain Injury Model Systems: a longitudinal database, research, collaboration and knowledge translation. Eur J Phys Rehabil Med. 2010 Dec;46(4):549-56.

Wagner AK, Miller MA, Scanlon J, Ren D, Kochanek PM, Conley YP: Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI. Epilepsy Res. 2010 Aug;90(3):259-72

2009

Abrahamson EE, Ikonomovic MD, Dixon CE, DeKosky ST:  Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.  Ann Neurol. 2009 Sep;66(3):407-14.

Au AK, Bayır H, Kochanek PM, Clark RS:  Evaluation of autophagy using mouse models of brain injury.  Biochim Biophys Acta. 2010 Oct;1802(10):918-23

Berger RP, Richichi R:  Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum.  Pediatr Crit Care Med 2009 Mar;10(2):260-3.

Belikova NA, Glumac A, Rafikov R, Jiang J, Greenberger JS, Kagan VE, Bayir H:  Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.  FEBS Lett. 2009 Nov 3;583(21):3437-42.

Campbell KA, Squires J, Cook LJ, Berger RP:  Disparities in the medical examination of children in the home of a child with suspected physical abuse.  Child Abuse Negl. 2009 Sep;33(9):612-7.

Christenson J, Andrusiek D, Everson-Stewart S, Kudenchuk P, Hostler D, Powell J, Callaway CW, Bishop D, Vaillancourt C, Davis D, Aufderheide TP, Idris A, Stouffer JA, Stiell I, Berg R; Resuscitation Outcomes Consortium Investigators:  Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation.  Circulation. 2009 Sep 29;120(13):1241-7.

Bales JW, Wagner AK, Kline AE, Dixon CE:  Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis.  Neurosci Biobehav Rev. 2009 Jul;33(7):981-1003.

Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM: Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med. 2009 Feb;37(2):689-95. Erratum in: Crit Care Med. 2009 Apr;37(4):1536.

Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE: Peroxidase mechanism of lipid dependent cross-linking of synuclein with cytochrome c: protection against apoptosis versus delayed oxidative stress in Parkinson's disease. J Biol Chem. 2009 Jun 5;284(23):15951-69.

Belikova NA, Jiang J, Stoyanovsky DA, Glumac A, Bayir H, Greenberger JS, Kagan VE: Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO() and protects mouse embryonic cells against irradiation-induced apoptosis. FEBS Lett. 2009 Jun 18;583(12):1945-50

Bell MJ, Carpenter J, Au AK, Keating RF, Myseros JS, Yaun A, Weinstein S:  Development of a Pediatric Neurocritical Care Service. Neurocrit Care. 2009;10(1):4-10.

Berger RP, T’asan S, Rand A, Lokshin A, Kochanek P:   Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury.  Pediatr Res. 2009 Jan;65(1):97-102.

Berger R, Richichi R:  Derivation and validation of an equation for adjustment of neuron-specific enolase concentrations in hemolyzed serum.  Pediatr Crit Care Med. 2009 Mar;10(2):260-3.

Chu CT, Plowey ED, Dagda RK, Hickey RW, Cherra SJ 3rd, Clark RS: Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol. 2009;453:217-49.

Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, Clark RS, Jenkins LW, Dixon CE, Kochanek PM:  Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.  J Neurotrauma. 2009 Jun;26(6):889-99.

Dietrich WD, Bullock MR, Kochanek PM: Hypothermic therapies targeting brain and spinal cord injury. Introduction. J Neurotrauma. 2009 Mar;26(3):297-8.

Drabek T, Tisherman SA, Beuke L, Stezoski J, Janesko-Feldman K, Lahoud-Rahme M, Kochanek PM: Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats. Anesth Analg. 2009 Sep;109(3):914-23

Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS: Starving neurons show sex difference in autophagy. J Biol Chem. 2009 Jan 23;284(4):2383-96.

Exo J, Shellington D, Bayir H, Vagni V, Janesko KL, Ma L, Hsia CJ, Clark R, Jenkins LW, Dixon CE, Kochanek PM: Resuscitation of Traumatic Brain Injury and Hemorrhagic Shock with Polynitroxylated Albumin, Hextend, Hypertonic Saline and Lactated Ringers: Effects on Acute Hemodynamics, Survival, and Neuronal Death in Mice. J Neurotrauma. 2009 Dec;26(12):2403-8.

Foley LM, Hitchens TK, Ho C, Janesko KL, Melick JA, Bayir H, Kochanek PM: Magnetic Resonance Imaging Assessment of Macrophage Accumulation in Mouse Brain after Experimental Traumatic Brain Injury. J Neurotrauma. 2009 Sep;26(9):1509-19.

Hicks SD, Salcido DD, Logue ES, Suffoletto BP, Empey PE, Poloyac SM, Miller DR, Callaway CW, Menegazzi JJ:  Lipid Emulsion Combined with Epinephrine and Vasopressin Does Not Improve Survival in a Swine Model of Bupivacaine-induced Cardiac Arrest.  Anesthesiology. 2009 Jul;111(1):138-46.

Holevar M, Dunham JC, Brautigan R, Clancy TV, Como JJ, Ebert JB, Griffen MM, Hoff WS, Kurek SJ Jr, Talbert SM, Tisherman SA:  Practice management guidelines for timing of tracheostomy: the EAST practice management guidelines work group.  J Trauma. 2009 Oct;67(4):870-4.

Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, Bayir H:  Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions.  Adv Drug Deliv Rev. 2009 Nov 30;61(14):1375-85.

Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA: Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. Mol Nutr Food Res. 2009 Jan;53(1):104-14. Review.

Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G: Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med. 2009 Jun 1;46(11):1439-53.

Kampmeyer M, Callaway C:  Method of cold saline storage for prehospital induced hypothermia.  Prehosp Emerg Care. 2009 Jan-Mar;13(1):81-4

Kapralov A, Vlasova II, Feng W, Maeda A, Walson K, Tyurin VA, Huang Z, Aneja RK, Carcillo J, Bayir H, Kagan VE:  Peroxidase activity of hemoglobin x haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages.  J Biol Chem. 2009 Oct 30;284(44):30395-407.

Kochanek PM, Tasker RC:  Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care.  Pediatr Crit Care Med. 2009 Jul;10(4):517-23

Kochanek PM: Bakken Lecture: the brain, the heart, and therapeutic hypothermia. Cleve Clin J Med. 2009 Apr;76 Suppl 2:S8-12.

Kochanek PM, Bauman RA, Long J, Dixon CE, Jenkins LW:  A critical problem begging for new insight and new therapies.  J Neurotrauma. 2009 Jun;26(6):813-4.

Kochanek PM, Drabek T, Tisherman SA: Therapeutic hypothermia: the Safar vision. J Neurotrauma. 2009 Mar;26(3):417-20.

Kochanek PM, Fink EL, Bell MJ, Bayir H, Clark RS: Therapeutic hypothermia: applications in pediatric cardiac arrest. J Neurotrauma. 2009 Mar;26(3):421-7.

Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Fadeel B, Kichambare PD, Star A, Kisin ER, Murray AR, Shvedova AA, Kagan VE: Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS ONE. 2009;4(2):e4398.

Lahoud-Rahme MS, Stezoski J, Kochanek PM, Melick J, Tisherman SA, Drabek T: Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation. Resuscitation. 2009 Apr;80(4):484-8.

Manole MD, Kochanek PM, Fink EL, Clark RS:  Postcardiac arrest syndrome: focus on the brain.  Curr Opin Pediatr. 2009 Dec;21(6):745-50.

Manole MD, Foley LM, Hitchens TK, Kochanek PM, Hickey RW, Bayır H, Alexander H, Ho C, Clark RS:  Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats.  J Cereb Blood Flow Metab. 2009 Jan;29(1):197-205.

Meert KL, Donaldson A, Nadkarni V, Tieves KS, Schleien CL, Brilli RJ, Clark RS, Shaffner DH, Levy F, Statler K, Dalton HJ, van der Jagt EW, Hackbarth R, Pretzlaff R, Hernan L, Dean JM, Moler FW; for the Pediatric Emergency Care Applied Research Network:  Multicenter cohort study of in-hospital pediatric cardiac arrest.  Pediatr Crit Care Med. 2009 Sep;10(5):544-53.

Moler FW, Meert K, Donaldson AE, Nadkarni V, Brilli RJ, Dalton HJ, Clark RS, Shaffner DH, Schleien CL, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Levy F, Hernan L, Silverstein FS, Dean JM; for the Pediatric Emergency Care Applied Research Network:  In-hospital versus out-of-hospital pediatric cardiac arrest: A multicenter cohort study.  Crit Care Med. 2009 Jul;37(7):2259-67.

Mumma BE, Shellenbarger D, Callaway CW, Katz KD, Guyette FX, Rittenberger JC: Neurologic recovery following cardiac arrest due to carbon monoxide poisoning. Resuscitation. 2009 Dec;80(12):1446-7.

Napolitano LM, Kurek S, Luchette FA, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA, Corwin HL, Barie PS, Tisherman SA, Hebert PC; EAST Practice Management Workgroup; American College of Critical Care Medicine (ACCM) Taskforce of the Society of Critical Care Medicine (SCCM):  Clinical practice guideline: red blood cell transfusion in adult trauma and critical care.  J Trauma. 2009 Dec;67(6):1439-42.

Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA; American College of Critical Care Medicine of the Society of Critical Care Medicine; Eastern Association for the Surgery of Trauma Practice Management Workgroup:  Clinical practice guideline: red blood cell transfusion in adult trauma and critical care.  Crit Care Med. 2009 Dec;37(12):3124-57.

Newgard CD, Rudser K, Atkins DL, Berg R, Osmond MH, Bulger EM, Davis DP, Schreiber MA, Warden C, Rea TD, Emerson S; ROC Investigators:  The availability and use of out-of-hospital physiologic information to identify high-risk injured children in a multisite, population-based cohort.  Prehosp Emerg Care. 2009 Oct-Dec;13(4):420-31.

Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Bbttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV:  Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke (Part 1).  Int Emerg Nurs. 2009 Oct;17(4):203-25.

Ochalski PG, Okonkwo DO, Bell MJ, Adelson PD: Reversal of sedation with flumazenil in a child after traumatic brain injury. J Neurosurg Pediatr. 2009 Mar;3(3):240-3.

Puccio AM, Hoffman LA, Bayir H, Zullo TG, Michael FR, Darby JM, Alexander SA, Dixon CE, Okonkwo DO, Kochanek PM:  Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury.  J Neurotrauma. 2009 Aug;26(8):1241-9.

Reynolds JC, Callaway CW, El Khoudary SR, Moore CG, Alvarez RJ, Rittenberger JC: Review of A Large Clinical Series: Coronary Angiography Predicts Improved Outcome Following Cardiac Arrest: Propensity-adjusted Analysis. J Intensive Care Med. 2009 May-Jun;24(3):179-86.

Rittenberger JC, Callaway CW: Transport of Patients After Out-of-Hospital Cardiac Arrest: Closest Facility or Most Appropriate Facility? Ann Emerg Med. 2009 Aug;54(2):256-7

Sanchez de Toledo J, Adelson PD, Watson RS, Gaines B, Brown SD, Kochanek PM, Wisniewski SR, Fink E, Bayır H, Clark RS, Bell MJ: Relationship Between Increases in Pancreatic Enzymes and Cerebral Events in Children After Traumatic Brain Injury. Neurocrit Care. 2009 Aug 11. [Epub ahead of print]

Shvedova AA, Kagan VE: Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS ONE. 2009;4(2):e4398

Suffoletto B, Peberdy MA, van der Hoek T, Callaway C:  Body temperature changes are associated with outcomes following in-hospital cardiac arrest and return of spontaneous circulation.  Resuscitation. 2009 Dec;80(12):1365-70.

Tortorici MA, Mu Y, Kochanek PM, Xie W, Poloyac SM: Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. Crit Care Med. 2009 Jan;37(1):263-9.

Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayır H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE: Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2863-72.

Wagner AK, Drewencki LL, Chen X, Santos FR, Khan AS, Harun R, Torres GE, Michael AC, Dixon CE: Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury. J Neurochem. 2009 Feb;108(4):986-97.

Wagner AK, Sokoloski JE, Chen X, Harun R, Clossin DP, Khan AS, Andes-Koback M, Michael AC, Dixon CE:  Controlled Cortical Impact Injury Influences Methylphenidate Induced Changes In Striatal Dopamine Neurotransmission.  J Neurochem. 2009 Aug;110(3):801-10.

Wang HE, Simeone SJ, Weaver MD, Callaway CW:  Interruptions in cardiopulmonary resuscitation from paramedic endotracheal intubation.  Ann Emerg Med. 2009 Nov;54(5):645-652.e1.

2008

Ahmad M, Rose ME, Vagni V, Griffith RP, Dixon CE, Kochanek PM, Hickey RW, Graham SH:  Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice.  J Neurosci Res. 2008 Dec;86(16):3605-12.

Au AK, Ray PE, McBryde KD, Newman KD, Weinstein SL, Bell MJ:  Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions.  J Pediatr 152:33-38, 2008.

Bayır H, Kagan VE:  Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory. Crit Care 12:206, 2008.

Bell MJ, Kochanek PM: Traumatic brain injury in children: recent advances in management. Indian J Pediatr. 2008 Nov;75(11):1159-65.

Betz AE, Callaway CW, Hostler D, Rittenberger JC: Work of CPR during two different compression to ventilation ratios with real-time feedback. Resuscitation. 2008 Nov;79(2):278-82.

Callaway CW:  Why does the sensitivity of computed tomographic scan for detecting subarachnoid blood never improve? Ann Emerg Med 2008; 51:705-706.

Callaway CW, Ramos R, Logue ES, Betz AE, Wheeler M, Repine MJ: Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats. Neurosci Lett. 2008 Nov 7;445(1):103-7.

Cheng JP, Hoffman AN, Zafonte RD, Kline AE: A delayed and chronic treatment regimen with the 5-HT(1A) receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning.  Behav Brain Res 194:79-85, 2008.

Clark RS, Bayır H, Chu CT, Alber SM, Kochanek PM, Watkins SC:  Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4:88-90, 2008.

Crane SA, Callaway CW, Milbrandt EB, Huang DT:  Rethinking bystander CPR for out-of-hospital cardiac arrest. Crit Care 12:302, 2008.

Drabek T, Han F, Garman RH, Stezoski J, Tisherman SA, Stezoski SW, Morhard RC, Kochanek PM:  Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation.  Resuscitation 77:220-228, 2008.

Drabek T, Kochanek PM:  In quest of the optimal cooling device: isn’t faster “too fast”? Crit Care Med 36:1018-1020, 2008.

Fink EL, Lai Y, Zhang X, Janesko-Feldman K, Adelson PD, Szabó C, Berger RP, Sarnaik AA, Kochanek PM, Clark RS:  Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury. J Cereb Blood Flow Metab 28:1523-1529, 2008.

Foley LM, Hitchens TK, Melick JA, Bayır H, Ho C, Kochanek PM:  Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice.  J Neurotrauma 25:299-310, 2008.

Han F, Drabek T, Stezoski J, Janesko-Feldman K, Stezoski SW, Clark RS, Bayır H, Tisherman SA, Kochanek PM:  Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.  Resuscitation. 2008 Nov;79(2):301-10.

Hartman M, Watson RS, Linde-Zwirble W, Clermont G, Weissfeld L, Lave JR, Kochanek P, Angus D:  Pediatric traumatic brain injury is inconsistently regionalized in the US.  Pediatrics 122(1):e172-80, 2008.

Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD, Kline AE: Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience.  Neurosci Lett 431:226-230, 2008.

Hoffman AN, Cheng JP, Zafonte RD, Kline AE:  Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits. Life Sci 83:602-607, 2008.

Hsu AA, Fenton K, Weinstein S, Carpenter J, Dalton H, Bell MJ:  Neurological injury markers in children with septic shock. Pediatr Crit Care Med 9:245-251, 2008.

Kline AE, Hoffman AN, Cheng JP, Zafonte RD, Massucci JL: Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury. Neurosci Lett. 2008 Dec 31;448(3):263-7.

Kochanek PM, Berger RP, Bayr H, Wagner AK, Jenkins LW, Clark RS:  Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making.  Curr Opin Crit Care 14:135-141, 2008.

Kochanek PM, Bell MJ, Adelson PD:  Hypothermia therapy after traumatic brain injury in children.  N Engl J Med 359:1179; author reply 1180, 2008.

Lai Y, Hickey RW, Chen Y, Bayır H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS:  Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.  J Cereb Blood Flow Metab 28:540-550, 2008.

Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabo C, Clark RS:  Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.  J Neurochem 104:1700-1711, 2008.

Majerske CW, Mihalik JP, Ren D, Collins MW, Reddy CC, Lovell MR, Wagner AK:  Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performance. J Athl Train  43:265-274, 2008.

Manole MD, Hickey RW, Clark RS, Kochanek PM:  Current and future therapies of pediatric cardiopulmonary arrest.  Indian J Pediatr  75:609-614, 2008.

Moore TM, Callaway CW, Hostler D:  Core temperature cooling in healthy volunteers after rapid intravenous infusion of cold and room temperature saline solution.  Ann Emerg Med 51:153-159, 2008.

Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT Jr, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Vanden Hoek T: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation. 2008 Dec 2;118(23):2452-83.

Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, Rea T, Lowe R, Brown T, Dreyer J, Davis D, Idris A, Stiell I; Resuscitation Outcomes Consortium Investigators: Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA. 2008 Sep 24;300(12):1423-31. Erratum in: JAMA. 2008 Oct 15;300(15):1763.

Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation. 2008 Dec;79(3):350-79.

Raina KD, Callaway C, Rittenberger JC, Holm MB: Neurological and functional status following cardiac arrest: method and tool utility. Resuscitation. 2008 Nov;79(2):249-56.

Rittenberger JC, Hostler DP, Tobin T, Gaines J, Callaway CW:  Predictors of ROSC in witnessed aeromedical cardiac arrests.  Resuscitation 76:43-64, 2008

Rittenberger JC, Guyette FX, Tisherman SA, DeVita MA, Alvarez RJ, Callaway CW: Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest. Resuscitation. 2008 Nov;79(2):198-204.

Sarnaik AA, Conley YP, Clark RS: Susceptibility to meningococcal infection--nature versus nurture? Pediatr Crit Care Med. 2008 Sep;9(5):540-2.

Sharangpani A, Takanohashi A, Bell MJ:  Caspase activation in fetal rat brain following experimental intrauterine inflammation. Brain Res 1200C:138-145, 2008.

Tehranian R, Rose ME, Vagni V, Pickrell AM, Griffith RP, Liu H, Clark RSB, Dixon CE, Kochanek PM, Graham SH:  Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury. J Neurotrauma 25:755-767, 2008.

Tisherman SA, Bokhari F, Collier B, Cumming J, Ebert J, Holevar M, Kurek S, Leon S, Rhee P:  Clinical practice guideline: penetrating zone II neck trauma. J Trauma 64:1392-405, 2008.

Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayir H, Kagan VE: Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis. J Neurochem. 2008 Dec;107(6):1614-33.

Tyurin VA, Tyurina YY, Kochanek PM, Hamilton R, DeKosky ST, Greenberger JS, Bayır H, Kagan VE:  Oxidative lipidomics of programmed cell death.  Methods Enzymol 442:375-393, 2008.

Wu X, Drabek T, Tisherman SA, Henchir J, Stezoski SW, Culver S, Stezoski J, Jackson EK, Garman R, Kochanek PM:  Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs. J Cereb Blood Flow Metab 28:302-311, 2008.

2007

Bayır H, Kagan VE, Clark RSB, Janesko-Feldman K, Zhang X, Vagni V, Billiar TR, Kochanek PM:  Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.  J Neurochem 101:168-181, 2007.

Bayır H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL, Alexander H, Basova LV, Clark RS, Kochanek PM, Kagan VE: Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis.  Ann Neurol 62:154-169, 2007.

Beers SR, Berger RP, Adelson PD: Outcomes; Neurocognitive Outcome and Serum Biomarkers in Inflicted versus Non-Inflicted Traumatic Brain Injury in Young Children. J Neurotrauma 24:97-105, 2007.

Berger RP, Beers SR, Richichi R, Wiesman D, Adelson PD:  Serum biomarker concentrations and outcome after pediatric traumatic brain injury.  J Neurotrauma 24:1793-1801, 2007.

Buttram SD, Wisniewski SR, Jackson EK, Adelson PD, Feldman K, Bayir H, Berger RP, Clark RS, Kochanek PM:  Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: Effects of moderate hypothermia. J Neurotrauma 24:1707-1718, 2007.

Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J:  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.  J Neurosci 27:9278-9293, 2007.

Cheng JP, Aslam HA, Hoffman AN, Zafonte RD, Kline AE:  The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.  Neurosci Lett 416:165-8, 2007.

Clark RSB, Nathaniel PD, Zhang X, Dixon CE, Alber S, Watkins SC, Melick J, Kochanek PM, Graham SH: boc-Aspartyle(OMe)-Fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 27:316-326, 2007.

Clark RS, Vagni VA, Nathaniel PD, Jenkins LW, Dixon CE, Szabo C:  Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.  J Neurotrauma 24:1399-1405, 2007.

DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RS, Ikonomovic MD:  Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol Apr;64:541-544, 2007.

Dennis AM, Kochanek PM: Pathobiology of Blast Injury. Yearbook of Intensive Care and Emergency Medicine, J. L. Vincent (ed). Springer-Verlag, Berlin. pp. 1011-1022, 2007.. Springer-Verlag, Berlin. pp. 1011-1022, 2007.

Dixon CE, Kline AE. Neurotransmitters and electrophysiology in brain injury. In: Nervous System Dysfunction and Injury (Banik NL, Vol. Editor). Handbook of Neurochemistry and Molecular Neurobiology, Volume 24 Springer. (In press, 2007).

Drabek T, Fisk JA, Dixon CE, Garman RH, Stezoski J, Wisniewski SR, Wu X, Tisherman SA, Kochanek PM:  Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficit.  Life Sci 81:543-552, 2007.

Drabek T, Stezoski J, Garman RH, Wu X, Tisherman SA, Stezoski SW, Fisk JA, Jenkins L, Kochanek PM: Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial. Crit Care Med 35:532-537, 2007. Accompanying editorial by Alam HB. To cool or not to cool, that is the question. Crit Care Med 35:660-662, 2007.

Drabek T, Stezoski J, Garman RH, Han F, Henchir J, Tisherman SA, Stezoski SW, Kochanek PM:  Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome. Resuscitation 75:114-123, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Winning the cold war: Inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Crit Care Med 35:1199-1202, 2007.

Fink EL, Callaway CW, Tisherman SA, Kochanek PM:  Hypothermia in traumatic brain injury.  Crit Care Med 35:1999-2000, 2007.

Gao W, Chadha MS, Berger RP, Omenn G, Allen D, Pisano M, Adelson PD, Clark RSB, Jenkins LW, Kochanek PM: Biomarkers and diagnosis: A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. J Neurotrauma: 24:43-53, 2007.

Ho Y, Logue E, Callaway CW, Defranco DB: Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion. Neuroscience 145:248-55, 2007.

Hostler D, Callaway CW, Newman DH, D'Cruz B: Thrombin-Antithrombin Appearance in Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care 11:9-13, 2007.

Hostler D, Rittenberger JC, Roth R, Callaway CW:  Increased chest compression to ventilation ratio improves delivery of CPR. Resuscitation 74:446-452, 2007.

Janata A, Bayegan K, Weihs W, Schratter A, Holzer M, Frossard M, Sipos W, Springler G, Schmidt P, Sterz F, Losert UM, Laggner AN, Kochanek PM, Behringer W:  Emergency preservation and resuscitation improve survival after 15 minutes of normovolemic cardiac arrest in pigs.  Crit Care Med 35:2785-2791, 2007.

Kagan VE, Jiang J, Bayır H, Stoyanovsky DA:  Targeting nitroxides to mitochondria: location, location, location, and …concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide".  Free Radic Biol Med 43:348-350, 2007.

Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayır H, Vladimirov YA, Kagan VE:  The Hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.  Biochemistry 46:14232-14244, 2007.

Kentner R, Safar P, Behringer W, Wu X, Henchir J, Ma L, Hsia CJ, Tisherman SA:  Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats. Resuscitation 72:295-305, 2007.

Kline AE, Wagner AK, Westergom BP, Malena RR, Zafonte RD, Olsen AS, Sozda CN, Luthra P, Panda M, Cheng JP, Aslam HA:  Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma. Behav Brain Res 177:186-194, 2007.

Kline AE, Massucci JL, Zafonte RD, Dixon CE, Defeo JR, Rogers EH:  Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma.  Crit Care Med 35:919-924, 2007.

Kochanek PM, Berger RP, Margulies SS, Jenkins LW: Inflicted childhood neurotrauma: new insight into the detection, pathobiology, prevention, and treatment of our youngest patients with traumatic brain injury. J Neurotrauma 24:1-4, 2007.

Lo BM, Quinn SM, Hostler D, Callaway CW:  Rescue shock outcomes during out-of-hospital cardiac arrest.  Resuscitation 75:469-475, 2007.

Logue ES, McMichael MJ, Callaway CW:  Comparison of the effects of hypothermia at 33˚C or 35˚C after cardiac arrest in rats.  Acad Emerg Med 14:293-300, 2007.

Rittenberger JC, Menegazzi JJ, Callaway CW: Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrest.  Resuscitation 73:154-160, 2007.

Shore PM, Berger RP, Varma S, Janesko KL, Wisniewski SR, Clark RS, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PM: Biomarkers and Diagnosis; Cerebrospinal Fluid Biomarkers versus Glasgow Coma Scale and Glasgow Outcome Scale in Pediatric Traumatic Brain Injury: The Role of Young Age and Inflicted Injury. J Neurotrauma 24:75-86, 2007.

Stippler M, Fischer MR, Puccio AM, Wisniewski SR, Carson-Walter EB, Dixon CE, Walter KA:  Serum and cerebrospinal fluid magnesium in severe traumatic brain injury outcome.  J Neurotrauma 24:1347-1354, 2007.

Tortorici MA, Kochanek PM, Poloyac SM:  Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.  Crit Care Med 35:2196-2204, 2007. Review.

Tyurina YY, Basova LV, Konduru NV, Tyurin VA, Potapovich AI, Cai P, Bayır H, Stoyanovsky D, Pitt BR, Shvedova AA, Fadeel B, Kagan VE: Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation.  J Biol Chem 282:8498-8509, 2007.

Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayır H, Kagan VE. Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis. Cell Death Differ 14:872-875, 2007.

Venneti S, Wagner AK, Wang G, Slagel SL, Chen X, Lopresti BJ, Mathis CA, Wiley CA:  The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.  Exp Neurol 207:118-127, 2007.

Wagner AK, McElligott J, Chan L, Wagner EP 2nd, Segal NA, Gerber LH:   How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee.  Arch Phys Med Rehabil 2007 May; 88(5):560-568.

Wagner AK, Kline AE, Ren D, Willard LA, Wenger MK, Zafonte RD, Dixon CE:  Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury.  Behav Brain Res 181(2):200-209.

Wagner AK, Ren D, Conley YP, Ma X, Kerr ME, Zafonte RD, Puccio AM, Marion DW, Dixon CE:  Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury.  J Neurosurg 106(4):538-547, 2007.

Wagner AK, Postal BA, Darrah SD, Chen X, Khan AS: Deficits in novelty exploration after controlled cortical impact.  J Neurotrauma 24:1308-1320, 2007.

Yan HQ, Ma X, Chen X, Li Y, Shao L, Dixon CE: Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res 1134:171-179, 2007.