Hypothermia and Drug Metabolism Featured in Critical Connections

An article in the June/July edition of Critical Connections written by Safar Center Associate Director Dr. Sam Poloyac and his mentee, School of Pharmacy PhD candidate Kacey Anderson, highlights new research into how therapeutic hypothermia affects the metabolism rate of specific drugs. Members of Dr. Poloyac’s team at the University of Pittsburgh School of Pharmacy are leaders in the field on research in the area of the effect of therapeutic hypothermia on drug metabolism. Notably, their work has focused on the cytochrome P-450 system. The hope is that a better understanding of the impact of hypothermia on drug metabolism will allow for more targeted medication dosage during cooling and thus reduces toxicity and improves outcome. Read the full article here.