Dr. Erik Brockman Publishes New Findings on PNPH

Erik Brockman, MD, a current T32 Fellow at the Safar Center, recently published a new article in the Journal of Cerebral Blood Flow and Metabolism titled, “Polynitroxylated pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice.” Dr. Brockman reported the results of his study wherein mice underwent traumatic brain injury followed by controlled hemorrhagic shock and were immediately resuscitated with polynitroxylated pegylated hemoglobin (PNPH). Compared to standard resuscitation with lactated Ringer’s (LR) solution, mice resuscitated with PNPH required dramatically less fluid for resuscitation.  Additionally, mice resuscitated with PNPH had significantly lower intracranial pressures and brain edema, felt to be a direct benefit to the reduced fluid requirements for resuscitation and the novel composition of PNPH. PNPH is a unique covalently modified bovine hemoglobin with nitroxide and polyethylene glycol moieties that is being developed as a small volume resuscitative fluid and nanotherapeutic. These encouraging results support ongoing pre-clinical investigation of this novel resuscitation fluid that is currently being funded by a U44 grant from the NINDS. The work represents research done in collaboration with Dr. Carleton Hsia at SynZyme Technologies LLC and Dr. Li Ma at Georgia Southern University.