Anthony Kline, PhD, Professor of Physical Medicine and Rehabilitation and Associate Director of the Safar Center for Resuscitation Research, recently received a notification that his R21 grant, entitled “Effects of Chronic Adolescent Stress on Cognitive and Emotional Behavior After Adult TBI,” will be funded by National Institute of Neurological Disorders and Stroke (NINDS).
The overarching aims of the study are to test the hypothesis that chronic unpredictable stress provided during adolescence will result in deleterious effects on anxiety, depression, and cognition in rats subjected to a TBI as adults. Moreover, the endocannabinoid system may underlie the molecular mechanisms involved in these behavioral changes, and thus treatment with the CB1 agonist ACEA will reduce the deleterious effects of adolescent stress in adults sustaining a TBI. Dr. Corina Bondi, PhD, will be the Co-Investigator on the study, and Dr. Patricia de la Tremblaye, PhD, will serve as Postdoctoral Fellow. Please join us in congratulating them on this achievement.