2019 Publications

Articles are listed in the order they are e-published.


Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats. Fortress AM, Avcu P, Wagner AK, Dixon CE, Pang KCH. Exp Neurol. 2019 May;315:42-51.


Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model. Di Caro V, Cummings JL, Alcamo AM, Piganelli JD, Clark RSB, Morowitz MJ, Aneja RK. Shock. 2019 Apr;51(4):526-534. 

Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayır H. Crit Care Med. 2019 Apr;47(4):e292-e300. 

New Developments for Pediatric Critical Care Medicine in 2019 and Beyond.Kochanek PM, Kudchadkar SR, Kissoon N. Pediatr Crit Care Med. 2019 Apr;20(4):311.

PICU-Based Rehabilitation and Outcomes Assessment: A Survey of Pediatric Critical Care Physicians.Treble-Barna A, Beers SR, Houtrow AJ, Ortiz-Aguayo R, Valenta C, Stanger M, Chrisman M, Orringer M, Smith CM, Pollon D, Duffett M, Choong K, Watson RS, Kochanek PM, Fink EL; PICU-Rehabilitation Study Group, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, and Prevalence of Acute critical Neurological disease in children: A Global Epidemiological Assessment (PANGEA) Investigators. Pediatr Crit Care Med. 2019 Apr 3.  [Epub ahead of print]


Variability in daily self-reported emotional symptoms and fatigue measured over eight weeks in community dwelling individuals with traumatic brain injury. Juengst SB, Terhorst L, Kew CL, Wagner AK. Brain Inj. 2019;33(5):567-573. doi: 10.1080/02699052.2019.1584333. Epub 2019 Mar 5.

Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level. Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H, Kagan VE, Winograd N. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161.

"Redox lipidomics technology: Looking for a needle in a haystack".Tyurina YY, Tyurin VA, Anthonymuthu T, Amoscato AA, Sparvero LJ, Nesterova AM, Baynard ML, Sun W, He R, Khaitovich P, Vladimirov YA, Gabrilovich DI, Bayır H, Kagan VE. Chem Phys Lipids. 2019 Mar 27;221:93-107.

Environmental enrichment and amantadine confer individual but nonadditive enhancements in motor and spatial learning after controlled cortical impact injury. Bleimeister IH, Wolff M, Lam TR, Brooks DM, Patel R, Cheng JP, Bondi CO, Kline AE. Brain Res. 2019 Mar 12. pii: S0006-8993(19)30139-8. [Epub ahead of print]

Primum non nocere: a call for balance when reporting on CTE. Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH. Lancet Neurol. 2019 Mar;18(3):231-233.  Epub 2019 Feb 12. Erratum in: Lancet Neurol. 2019 Apr;18(4):e3.

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H. Crit Care Med. 2019 Mar;47(3):410-418. 

Cooling via Trans-nasal High Flow Ambient Air: Does it Pass the Smell Test? Kochanek PM, Fink EL. Neurocrit Care. 2019 Mar 22. [Epub ahead of print] 

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-O'Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS. Pediatr Crit Care Med. 2019 Mar;20(3):280-289. 

Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, Selden NR, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Wainwright MS. Pediatr Crit Care Med. 2019 Mar;20(3):269-279. 

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines. Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-O'Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS. Pediatr Crit Care Med. 2019 Mar;20(3S Suppl 1):S1-S82. 


The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III. Frankel M, Fan L, Yeatts SD, Jeromin A, Vos PE, Wagner AK, Wolf BJ, Pauls Q, Lunney M, Merck LH, Hall CL, Palesch Y, Silbergleit R, David W. J Neurotrauma. 2019 Feb 22.  [Epub ahead of print]

Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury: Examining Associations With Demographics, Healthcare Utilization, Institutionalization, and 1-Year Outcomes. Kumar RG, Olsen J, Juengst SB, Dams-OʼConnor K, OʼNeil-Pirozzi TM, Hammond FM, Wagner AK. J Head Trauma Rehabil. 2019 Feb 27.  [Epub ahead of print]

A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls.Niemeier JP, Perrin PB, Hurst BS, Foureau DM, Huynh TT, Evans SL, Silverman JE, Elise McClannahan M, Brusch BD, Newman M, Mougeot JL, Wagner AK. Behav Neurol. 2019 Feb 12;2019:7694503.

Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members. Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I. J Chem Inf Model. 2019 Feb 28. doi: 10.1021/acs.jcim.9b00006. [Epub ahead of print]

A New Vision for Therapeutic Hypothermia in the Era of Targeted Temperature Management: A Speculative Synthesis. Jackson TC, Kochanek PM. Ther Hypothermia Temp Manag. 2019 Mar;9(1):13-47. doi:

Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications. Hagos FT, Adams SM, Poloyac SM, Kochanek PM, Horvat CM, Clark RSB, Empey PE.Exp Neurol. 2019 Feb 21. pii: S0014-4886(19)30024-X. doi: 10.1016/j.expneurol.2019.02.011. [Epub ahead of print].

Downstream TRPM4 Polymorphisms Are Associated with Intracranial Hypertension and Statistically Interact with ABCC8 Polymorphisms in a Prospective Cohort of Severe Traumatic Brain Injury. Jha RM, Desai SM, Zusman BE, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Kochanek PM, Conley YP. J Neurotrauma. 2019 Feb 1.  [Epub ahead of print]

2',3'-cGMP Exists In Vivo and Comprises a 2',3'-cGMP-Guanosine Pathway. Jackson EK, Mi Z, Janesko-Feldman K, Jackson TC, Kochanek PM.Am J Physiol Regul Integr Comp Physiol. 2019 Feb 21. [Epub ahead of print]

Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE. J Neurotrauma. 2019 Feb 1.  [Epub ahead of print]

Targeted Temperature Management for Everyone: A Call for Tailoring Guidelines Based on Resource Availability. Alcamo AM, Fink EL. Pediatr Crit Care Med. 2019 Feb;20(2):206-207.


Aripiprazole and environmental enrichment independently improve functional outcome after cortical impact injury in adult male rats, but their combination does not yield additional benefits. Besagar S, Radabaugh HL, Bleimeister IH, Meyer EA, Niesman PJ, Cheng JP, Bondi CO, Kline AE. Exp Neurol. 2019 Jan 16.[Epub ahead of print]

Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury. Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J. J Neurosci. 2019 Jan 9. [Epub ahead of print]

Intermittent Administration of Haloperidol after Cortical Impact Injury Neither Impedes Spontaneous Recovery Nor Attenuates the Efficacy of Environmental Enrichment. Bao GC, Bleimeister IH, Zimmerman LA, Wellcome JL, Niesman PJ, Radabaugh HL, Bondi CO, Kline AE. J Neurotrauma. 2019 Jan 9. [Epub ahead of print]

Chronic Treatment with Galantamine Rescues Reversal Learning in an Attentional Set-Shifting Test After Experimental Brain Trauma. Njoku I, Radabaugh HL, Nicholas MA, Kutash LA, O'Neil DA, Marshall IP, Cheng JP, Kline AE, Bondi CO. Exp Neurol. 2019 Jan 31. [Epub ahead of Print]