2018 Publications

Articles are listed in the order they are e-published.

September

A Big Loss for Our Field, But an Inspiration for Passion at the Bedside. Kochanek PM. Pediatr Crit Care Med. 2018 Sep;19(9):799.

August

Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes.Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM.Crit Care Med. 2018 Aug 16.

Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond. Kochanek PM, Dixon CE, Mondello S, Wang KKK, Lafrenaye A, Bramlett HM, Dietrich WD, Hayes RL, Shear DA, Gilsdorf JS, Catania M, Poloyac SM, Empey PE, Jackson TC, Povlishock JT. Front Neurol. 2018 Aug 7;9:640.

Pathophysiology and treatment of cerebral edema in traumatic brain injury. Jha RM, Kochanek PM, Simard JM. Neuropharmacology. 2018 Aug 4. pii: S0028-3908(18)30471-4. [Epub ahead of print].

July

Delayed and abbreviated environmental enrichment after brain trauma promotes motor and cognitive recovery that is not contingent on increased neurogenesis. Lajud N, Díaz-Chávez A, Radabaugh H, Cheng JP, Rojo-Soto G, Valdéz-Alarcón J, Bondi CO, Kline AE. J Neurotrauma. 2018 Jul 27. [Epub ahead of print]

Employment stability in the first 5 years after moderate to severe traumatic brain injury. DiSanto D, Kumar R, Juengst SB, Hart T, O'Neil-Pirozzi TM, Zasler N, Novack TA, Dillahunt-Aspillaga C, Graham KM, Cotner BA, Rabinowitz A, Dikmen S, Niemeier J, Kesinger MR, Wagner AK. Arch Phys Med Rehabil. 2018 Jul 25. pii: S0003-9993(18)30461-1.  [Epub ahead of print]

Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability or Cognitive Outcome in Global, Inducible HMGB1 Knockout Mice despite Tissue Sparing after Experimental Traumatic Brain Injury. Aneja RK, Alcamo A, Cummings JL, Vagni VA, Janesko-Feldman KL, Wang Q, Dixon CE, Billiar T, Kochanek PM. J Neurotrauma. 2018 Jul 26. [Epub ahead of print]

Serum-based phospho-neurofilament-heavy protein as theranostic biomarker in three models of traumatic brain injury: an Operation Brain Trauma Therapy (OBTT) study. Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf J, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock J, Tortella FC, Kochanek PM, Wang KKW. J Neurotrauma. 2018 Jul 10. [Epub ahead of print]

Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice. Cole LK, Kim JH, Amoscato AA, Tyurina YY, Bayır H, Karimi B, Siddiqui TJ, Kagan VE, Hatch GM, Kauppinen TM. Biochim Biophys Acta. 2018 Jul 25. [Epub ahead of print]

Aiming for the Target: Mitochondrial Drug Delivery in Traumatic Brain Injury. Lamade AM, Kenny EM, Anthonymuthu TS, Soysal E, Clark R, Kagan VE, Bayır H. Neuropharmacology. 2018 Jul 12. pii: S0028-3908(18)30375-7. Epub ahead of print] Review.

Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury. Sama DM, Carlson SW, Joseph B, Saenger S, Metzger F, Saatman KE. Restor Neurol Neurosci. 2018;36(4):559-569. 

Craniectomy and Craniotomy in Traumatic Brain Injury: A Propensity-Matched Analysis of Long-Term Functional and Quality of Life Outcomes. Kelly ML, Shammassian B, Roach MJ, Thomas C, Wagner AK. World Neurosurg. 2018 Jul 23. pii: S1878-8750(18)31602-4. [Epub ahead of print]

June

Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone. Carlson LJ, Bao GC, Besagar S, Leary JB, Radabaugh HL, Bondi CO, Kline AE. Neurosci Lett. 2018 Jun 6;682:69-73. [Epub ahead of print]

Novel therapies for combating chronic neuropathological sequelae of TBI. Ikonomovic MD, Abrahamson EE, Carlson SW, Graham SH, Dixon CE. Neuropharmacology. 2018 Jun 20.

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T. Clin Invest. 2018 Aug 1;128(8):3341-3355.  Epub 2018 Jun 25.

Oxidized phospholipid signaling in traumatic brain injury. Anthonymuthu TS, Kenny EM, Lamade AM, Kagan VE, Bayır H. Free Radic Biol Med. 2018 Jun 30;124:493-503. [Epub ahead of print] Review.

Systemic estrone production and injury induced sex hormone steroidogenesis after severe traumatic brain injury: a prognostic indicator of TBI-related mortality. Rakholia MV, Kumar RG, Oh BM, Ranganathan PR, Berga S, Kochanek PM, Wagner AK M.D. J Neurotrauma. 2018 Jun 27. [Epub ahead of print]

Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation. Lou W, Ting HC, Reynolds CJ, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayir H, Kagan VE, Greenberg ML.Biochim Biophys Acta. 2018 Jun 20. [Epub ahead of print]

Preclinical Models of Traumatic Brain Injury: Emerging Role of Glutamate in the Pathophysiology of Depression. O'Neil DA, Nicholas MA, Lajud N, Kline AE, Bondi CO. Front Pharmacol. 2018 Jun 1;9:579.. eCollection 2018. Review.

May

Regulation of lipid peroxidation and ferroptosis in diverse species. Conrad M, Kagan VE, Bayir H, Pagnussat GC, Head B, Traber MG, Stockwell BR. Genes Dev. 2018 May 1;32(9-10):602-619. Review.

Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury. Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayır H, Kochanek PM, Bell MJ, Clark RSB. Crit Care Med. 2018 May 7. [Epub ahead of print]

Preclinical Testing of Therapies for Traumatic Brain Injury. DeWitt D, Hawkins BE, Dixon CE, Kochanek PM, Armstead WM, Bass C', Bramlett HM, Büki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds Ii CSR, LaPlaca M, Long J, Meaney D, Mondello S, Noble-Haeusslein L, Poloyac SM, Prough DS, Robertson CS, Saatman KE, Shultz SR, Shear DA, Smith DH Dr, Valadka A, VandeVord PJ, Zhang L. J Neurotrauma. 2018 May 14. [Epub ahead of print]

Neurostimulant prescribing patterns in children admitted to the ICU after traumatic brain injury. Morrison AM, Houtrow A, Zullo J, Kochanek PM, Vetterly C, Fink EL. J Neurotrauma. 2018 May 14. [Epub ahead of print]

April

Lithium improves dopamine neurotransmission and increases dopaminergic protein abundance in the striatum after traumatic brain injury. Carlson SW, Dixon CE. J Neurotrauma. 2018 Apr 27. [Epub ahead of print]

The role of autophagy in acute brain injury: A state of flux? Wolf MS, Bayır H, Kochanek PM, Clark RSB. Neurobiol Dis. 2018 Apr 26. pii: S0969-9961(18)30133-5. 

Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP. J Neurol Neurosurg Psychiatry. 2018 Apr 19. pii: jnnp-2017-317741. [Epub ahead of print]

Probabilistic Matching of Deidentified Data From a Trauma Registry and a Traumatic Brain Injury Model System Center: A Follow-up Validation Study.Kumar RG, Wang Z, Kesinger MR, Newman M, Huynh TT, Niemeier JP, Sperry JL, Wagner AK. Am J Phys Med Rehabil. 2018 Apr;97(4):236-241.

Traumatic Brain Injury and Infectious Encephalopathy in Children From Four Resource-Limited Settings in Africa.Fink EL, von Saint Andre-von Arnim A, Kumar R, Wilson PT, Bacha T, Aklilu AT, Teklemariam TL, Hooli S, Tuyisenge L, Otupiri E, Fabio A, Gianakas J, Kochanek PM, Angus DC, Tasker RC; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, PALISI Global Health Subgroup, and Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment (PANGEA) Investigators.Pediatr Crit Care Med. 2018 Apr 16.  [Epub ahead of print]

March

Glibenclamide produces region-dependent effects on cerebral edema in a combined injury model of traumatic brain injury and hemorrhagic shock in mice. Jha R, Molyneaux BJ, Jackson TC, Wallisch J, Park SY, Poloyac SM, Vagni VA, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM. J Neurotrauma. 2018 Mar 8. doi: [Epub ahead of print]

Operation Brain Trauma Therapy: 2016 Update. Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA. Mil Med. March;183,(Sup 1):303–312

Presenting Predictors and Temporal Trends of Treatment-Related Outcomes in Diabetic Ketoacidosis.Horvat CM, Ismail HM, Au AK, Garibaldi L, Siripong N, Kantawala S, Aneja RK, Hupp DS, Kochanek PM, Clark RSB. Pediatr Diabetes. 2018 Mar 24. doi: 10.1111/pedi.12663. [Epub ahead of print]

Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology. Uray T, Lamade A, Elmer J, Drabek T, Stezoski JP, Missé A, Janesko-Feldman K, Garman RH, Chen N, Kochanek PM, Dezfulian C; University of Pittsburgh Post-Cardiac Arrest Service. Crit Care Med. 2018 Mar 10.[Epub ahead of print]

February

Environmental enrichment, alone or in combination with various pharmacotherapies, confers marked benefits after traumatic brain injury. de la Tremblaye PB, Cheng JP, Bondi CO, Kline AE.Neuropharmacology. 2018 Feb 27. [Epub ahead of print] Review.

Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients. Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB. Neurocrit Care. 2018 Feb;28(1):26-34. 
 
24 vs. 72 Hours of Hypothermia for Pediatric Cardiac Arrest: A Pilot, Randomized Controlled Trial. Fink EL, Clark RSB, Berger RP, Fabio A, Angus DC, Watson RS, Gianakas JJ, Panigrahy A, Callaway CW, Bell MJ, Kochaneka PM. Resuscitation. 2018 Feb 14.

Systemic administration of donepezil attenuates the efficacy of environmental enrichment on neurobehavioral outcome after experimental traumatic brain injury. Bondi CO, Yelleswarapu NK, Day-Cooney J, Memarzadeh K, Folweiler KA, Bou-Abboud CE, Leary JB, Cheng JP, Tehranian-DePasquale R, Kline AE. Restor Neurol Neurosci. 2018;36(1):45-57.

Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury. Carlson SW, Saatman KE. J Neurotrauma. 2018 Feb 17.  [Epub ahead of print]

A Special 50-Year Perspective on Our Field.Kochanek PM. Pediatr Crit Care Med. 2018 Feb 8.

January

Development and content validity of the behavioral assessment screening tool (BASTβ). Juengst SB, Terhorst L, Dicianno BE, Niemeier JP, Wagner AK. Disabil Rehabil. 2018 Jan 5:1-7.

Epidemiology of Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury. Kumar RG, Juengst SB, Wang Z, Dams-OʼConnor K, Dikmen SS, OʼNeil-Pirozzi TM, Dahdah MN, Hammond FM, Felix ER, Arenth PM, Wagner AK. J Head Trauma Rehabil. 2018 Jan/Feb;33(1):15-24.

Initiating Nutritional Support Before 72 Hours Is Associated With Favorable Outcome After Severe Traumatic Brain Injury in Children: A Secondary Analysis of a Randomized, Controlled Trial of Therapeutic Hypothermia. Meinert E, Bell MJ, Buttram S, Kochanek PM, Balasubramani GK, Wisniewski SR, Adelson PD; Pediatric Traumatic Brain Injury Consortium: Hypothermia Investigators. Pediatr Crit Care Med. 2018 Jan 24. 

The effects of post-traumatic depression on cognition, pain, fatigue, and headache after moderate-to-severe traumatic brain injury: a thematic review. Kumar RG, Gao S, Juengst SB, Wagner AK, Fabio A. Brain Inj. 2018 Jan 22:1-12. [Epub ahead of print]