2017 Publications

Articles are listed in the order they are e-published.

June

Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients. Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB. Neurocrit Care. 2017 Jun 13. [Epub ahead of print].

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0. Harun R, Grassi CM, Munoz MJ, Wagner AK. J Vis Exp. 2017 Jun 5;(124).

Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest. Prout AJ, Wolf MS, Fink EL. Curr Opin Pediatr. 2017 Jun;29(3):272-279.

May

Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2. Osier ND, Pham L, Pugh BJ, Puccio A, Ren D, Conley YP, Alexander S, Dixon CE. Neurosci Lett. 2017 May 22;650:18-24.

In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury. Liu H, Rose ME, Ma X, Culver S, Dixon CE, Graham SH. PLoS One. 2017 May 24;12(5):e0178049.

Guiding Pediatric Critical Care Medicine Toward a Bigger "Impression" in 2017 and Beyond. Kochanek PM, Kudchadkar SR, Kissoon N.Pediatr Crit Care Med. 2017 May;18(5):403-404.

Titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine. Kochanek PM, Bayir H. J Neurotrauma. 2017 May 24. [Epub ahead of print]

Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis. Morowitz MJ, Di Caro V, Pang D, Cummings J, Firek B, Rogers MB, Ranganathan S, Clark RSB, Aneja RK. Crit Care Med. 2017 May;45(5):e516-e523.

April

Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation. Brockman EC, Jackson TC, Dixon CE, Bayɪr H, Clark RS, Vagni V, Feldman K, Byrd C, Ma L, Hsia C, Kochanek PM. J Neurotrauma. 2017 Apr 1;34(7):1337-1350. 

Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury. Radabaugh HL, LaPorte MJ, Greene AM, Bondi CO, Lajud N, Kline AE. Exp Neurol. 2017 Apr 27;294:12-18. doi: 10.1016/j.expneurol.2017.04.013. [Epub ahead of print]

International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study. Fink EL, Kochanek PM, Tasker RC, Beca J, Bell MJ, Clark RS, Hutchison J, Vavilala MS, Fabio A, Angus DC, Watson RS; Prevalence of Acute critical Neurological disease in children: A Global Epidemiological Assessment (PANGEA) Investigators. Pediatr Crit Care Med. 2017 Apr;18(4):330-342.

Delirium in Critically Ill Children: An International Point Prevalence Study. Traube C, Silver G, Reeder RW, Doyle H, Hegel E, Wolfe HA, Schneller C, Chung MG, Dervan LA, DiGennaro JL, Buttram SD, Kudchadkar SR, Madden K, Hartman ME, deAlmeida ML, Walson K, Ista E, Baarslag MA, Salonia R, Beca J, Long D, Kawai Y, Cheifetz IM, Gelvez J, Truemper EJ, Smith RL, Peters ME, O'Meara AM, Murphy S, Bokhary A, Greenwald BM, Bell MJ. Crit Care Med. 2017 Apr;45(4):584-590. 

Derivation and Validation of a Serum Biomarker Panel to Identify Infants With Acute Intracranial Hemorrhage. Berger RP, Pak BJ, Kolesnikova MD, Fromkin J, Saladino R, Herman BE, Pierce MC, Englert D, Smith PT, Kochanek PM. JAMA Pediatr. 2017 Apr 10:e170429.

Ventricular Fibrillation Cardiac Arrest Produces a Chronic Striatal Hyperdopaminergic State that is Worsened by Methylphenidate Treatment. Nora GJ, Harun R, Fine DF, Hutchison D, Grobart AC, Stezoski JP, Munoz M, Kochanek PM, Leak RK, Drabek T, Wagner AK . J Neurochem. 2017 Apr 26.

Abusive Head Trauma and Mortality-An Analysis From an International Comparative Effectiveness Study of Children With Severe Traumatic Brain Injury. Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM; Investigators of the Approaches and Decisions in Acute Pediatric Traumatic Brain Injury (ADAPT) Trial. Crit Care Med. 2017 Apr 20.

ABCB1 genotype is associated with fentanyl requirements in critically Ill children. Horvat CM, Au AK, Conley YL, Kochanek PM, Li L, Poloyac SL, Empey PE, Clark RS. Pediatr Res. 2017 Apr 7. 

A "Metamorphosis" in Our Approach to Treatment Is Not Likely to Result From a Meta-Analysis of the Use of Therapeutic Hypothermia in Severe Traumatic Brain Injury. Wallisch JS, Kochanek PM. Crit Care Med. 2017 Apr;45(4):744-745.

March

Pediatric Multiple Organ Dysfunction in Resource Limited Settings. Fink EL, Kissoon N. Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S83-S85.

The far-reaching scope of neuroinflammation after traumatic brain injury. Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM. Nat Rev Neurol. 2017 Mar;13(3):171-191.

Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough? Dezfulian C, Taft M, Corey C, Hill G, Krehel N, Rittenberger JC, Guyette FX, Shiva S. Redox Biol. 2017 Mar 18;12:491-498.

Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest. Prout AJ1, Wolf MS, Fink EL. Curr Opin Pediatr. 2017 Mar 17.

Pediatric Multiple Organ Dysfunction in Resource Limited Settings. Fink EL, Kissoon N. Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S83-S85.

Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Crit Care Med. 2017 Mar;45(3):e255-e264

Physical and occupational therapy utilization in a pediatric intensive care unit. Cui LR, LaPorte M, Civitello M, Stanger M, Orringer M, Casey F 3rd, Kuch BA, Beers SR, Valenta CA, Kochanek PM, Houtrow AJ, Fink EL. J Crit Care. 2017 Mar 7;40:15-20. 

Psychometric evaluation of the pediatric and parent-proxy Patient-Reported Outcomes Measurement Information System and the Neurology and Traumatic Brain Injury Quality of Life measurement item banks in pediatric traumatic brain injury. Bertisch H, Rivara FP, Kisala PA, Wang J, Yeates KO, Durbin D, Zonfrillo MR, Bell MJ, Temkin N, Tulsky DS. Qual Life Res. 2017 Mar 7.

Pediatric cardiac arrest due to drowning and other respiratory etiologies: Neurobehavioral outcomes in initially comatose children. Slomine BS, Nadkarni VM, Christensen JR, Silverstein FS, Telford R, Topjian A, Koch JD, Sweney J, Fink EL, Mathur M, Holubkov R, Dean JM, Moler FW; Therapeutic Hypothermia after Pediatric Cardiac Arrest THAPCA Trial Investigators. Resuscitation. 2017 Mar 6. pii: S0300-9572(17)30104-1. 

Global assessment of oxidized free fatty acids in brain reveals an enzymatic predominance to oxidative signaling after trauma. Anthonymuthu TSKenny EMAmoscato AALewis JKochanek PMKagan VEBayır H. Biochim Biophys Acta. 2017 Mar 24.

Adenosine production by brain cells. Jackson EK, Kotermanski SE, Menshikova EV, Dubey RK, Jackson TC, Kochanek PM. J Neurochem. 2017 Mar 13. 

February

Contemporary animal models of cardiac arrest: A systematic review. Vognsen M, Fabian-Jessing BK, Secher N, Løfgren B, Dezfulian C, Andersen LW, Granfeldt A. Resuscitation. 2017 Apr;113:115-123. doi: 10.1016/j.resuscitation.2017.01.024. Epub 2017 Feb 15. 

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C. Br J Pharmacol. 2017 Feb 18. 

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children. Wallisch JS, Simon DW, Bayır H, Bell MJ, Kochanek PM, Clark RS.Neurocrit Care. 2017 Feb 8.

α-Tocopherol transfer protein mediates protective hypercapnia in murine ventilator-induced lung injury. Otulakowski G, Engelberts D, Arima H, Hirate H, Bayir H, Post M, Kavanagh BP. Thorax. 2017 Feb 3.

Acute Management of Refractory and Unstable Pediatric Supraventricular Tachycardia. Lewis JArora GTudorascu DLHickey RWSaladino RAManole MD. J Pediatr. 2017 Feb;181:177-182.e2. 

Tripartite Stratification of the Glasgow Coma Scale in Children with Severe Traumatic Brain Injury and Mortality: An Analysis from a Multi-Center Comparative Effectiveness Study. Murphy S, Thomas NJ, Gertz SJ, Beca J, Luther JF, Bell MJ, Wisniewski SR, Hartman AL, Tasker RC. J Neurotrauma. 2017 Feb 27.

Examining Emergency Department Treatment Processes in Severe Pediatric Traumatic Brain Injury. Ajdari A, Boyle LN, Kannan N, Rowhani-Rahbar A, Wang J, Mink R, Ries B, Wainwright M, Groner JI, Bell MJ, Giza C, Zatzick DF, Ellenbogen RG, Mitchell PH, Rivara FP, Vavilala MS. J Health Qual. 2017 Feb 3. 

The Brain and Hypothermia-From Aristotle to Targeted Temperature Management. Kochanek PM, Jackson TC. Crit Care Med. 2017 Feb;45(2):305-310

January

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. Tyurina YY, Lou W, Qu F, Tyurin VA, Mohammadyani D, Liu J, Hüttemann M, Frasso MA, Wipf P, Bayir H, Greenberg ML, Kagan VE. ACS Chem Biol. 2017 Jan 20;12(1):265-281.

 ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. Nat Chem Biol. 2017 Jan;13(1):91-98. 

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Nat Chem Biol. 2017 Jan;13(1):81-90. 

Known unknowns of cardiolipin signaling: The best is yet to come. Maguire JJ, Tyurina YY, Mohammadyani D, Kapralov AA, Anthonymuthu TS, Qu F, Amoscato AA, Sparvero LJ, Tyurin VA, Planas-Iglesias J, He RR, Klein-Seetharaman J, Bayır H, Kagan VE. Biochim Biophys Acta. 2017 Jan;1862(1):8-24. 

Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids. Kagan VE, Bayır H, Tyurina YY, Bolevich SB, Maguire JJ, Fadeel B, Balasubramanian K. Biochem Biophys Res Commun. 2017 Jan 15;482(3):482-490. 

Magic angle spinning 31P NMR spectroscopy reveals two essentially identical ionization states for the cardiolipin phosphates in phospholipid liposomes. Kooijman EE, Swim LA, Graber ZT, Tyurina YY, Bayır H, Kagan VE. Biochim Biophys Acta. 2017 Jan;1859(1):61-68. 

The benefits of youth are lost on the young cardiac arrest patient. Griffith B, Kochanek P, Dezfulian C. F1000Res. 2017 Jan 25;6:77.

Epidemiology of Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury. Kumar RG, Juengst SB, Wang Z, Dams-OʼConnor K, Dikmen SS, OʼNeil-Pirozzi TM, Dahdah MN, Hammond FM, Felix ER, Arenth PM, Wagner AK. J Head Trauma Rehabil. 2017 Jan 5.

Probabilistic Matching Approach to Link Deidentified Data from a Trauma Registry and a Traumatic Brain Injury Model System Center. Kesinger MR, Kumar RG, Ritter AC, Sperry JL, Wagner AK. Am J Phys Med Rehabil. 2017 Jan;96(1):17-24.

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC Jr, Clark AE, Dean JM; THAPCA Trial Investigators. N Engl J Med. 2017 Jan 26;376(4):318-329.