2015 Publications

Articles are listed in the order they are e-published.


Traumatic brain injury research highlights in 2015. Kochanek PM, Clark RS.Lancet Neurol. 2016 Jan;15(1):13-5. Epub 2015 Dec 8.

Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated Inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury. Harvey LD, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. ASN Neuro. 2015 Dec 18;7(6). 

Principal Components Derived from CSF Inflammatory Profiles Predict Outcome in Survivors after Severe Traumatic Brain Injury.Kumar RG, Rubin JE, Berger RPKochanek PMWagner AK. Brain Behav Immun. 2015 Dec 16. [Epub ahead of print]

Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury-Results From an Automated Data Collection System Time-Synched to Drug Administration. Shein SL, Ferguson NM, Kochanek PMBayir HClark RSFink EL, Tyler-Kabara EC, Wisniewski SR, Tian Y, Balasubramani GK, Bell MJ. Pediatr Crit Care Med. 2015 Dec 15. [Epub ahead of print]

Insight into Preclinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy. Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid Maj KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri S, Povlishock J, Tortella FC, Kochanek PM. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid Maj KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KK, Povlishock J, Tortella FC, Kochanek PM. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy. Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey P, Povlishock J, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri S, Tortella FC. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey P, Povlishock J, Tortella FC, Kochanek PM. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.Shear DA, Bramlett HM, Dixon CE, Dietrich WD, Deng-Bryant Y, Schmid Maj KE, Mondello S, Wang KK, Hayes RL, Povlishock J, Kochanek PM, Tortella FC. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid Maj KE, Mondello S, Wang KK, Hayes RL, Povlishock J, Tortella FC, Kochanek PM. J Neurotrauma. 2015 Dec 16. [Epub ahead of print]

Hidden Perils of the "Wild Blue Yonder" after Traumatic Brain Injury. Kochanek PM, Bayır H. J Neurotrauma. 2015 Dec 17. [Epub ahead of print]

Operation Brain Trauma Therapy: Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury. Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC. J Neurotrauma. 2015 Dec 10. [Epub ahead of print]

Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology. Fidan E, Lewis J, Kline AE, Garman RH, Alexander H, Cheng JP, Bondi CO, Clark RS, Dezfulian C,Kochanek PM, Kagan VE, Bayır H. J Neurotrauma. 2015 Dec 1. [Epub ahead of print]

Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals. Mao G, Qu F, St Croix CM, Tyurina YY, Planas-Iglesias J, Jiang J, Huang Z, Amoscato AA, Tyurin VA, Kapralov AA, Cheikhi A, Maguire J, Klein-Seetharaman J, Bayir H, Kagan VE. ACS Chem Biol. 2015 Dec 23. [Epub ahead of print]

Catecholaminergic based therapies for functional recovery after TBI. Osier ND, Dixon CE. Brain Res. 2015 Dec 19. [Epub ahead of print] 


Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD 3rd, Wang KK, Caudle KL, Empey P, Poloyac SM, Hayes RL, Povilshock J, Tortella FC, Kochanek PM, Shear DA. J Neurotrauma. 2015 Nov 5 [Epub ahead of print].


Pediatric Neurocritical Care: A Short Survey of Current Perceptions and Practices. Murphy SA, Bell MJ, Whalen MJ, Noviski N. Neurocritical Care. 2015 Oct 23(2):149-58.

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments, for a Multi-Center Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy. Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD 3rd, Schmid K, Mondello S, Wang KK, Hayes RL, Povlishock J, Tortella St FC. J Neurotrauma 2015 Oct 6. [Epub ahead of print]


It Seems Like Resuscitation Happened Ages Ago-Chronic Critical Illness in Children: Digging in for hte Long HaulFink EL, Kochanek PM. Crit Care Med 2015 Sep; 43(9):2035-6.


Pilot Feasibility of an mHealth System for Conduction Ecological Momentary Assessment of Mood-Related Symptoms Following Traumatic Brain Injury. Juengst SB, Graham KM, Pulantara IW, McCue M, Whyte EM, Dicianno BE, Paramanto B, Arenth OM, Skidmore ER, Wagner AK. Brain Inj 2015 Aug 7:1-11 [Epub ahead of print].

Defects of Lipid Synthesis Are Linked to the Age-Dependant Demyelination Caused by Lamin B1. Rolyan H, Tyurina Y, Hernande M, Amoscato AA, Sparvero L, Nmezi BC, Estecio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH,  Dupree J, Bayir H, Kagan VE, Casaccia P, Padiath QS.J Neurosci. 2015 Aug 26;35(34):12002-17

Cold Stress Protein RBM3 Responds to Temperature Change in an Ultra-Sensitive Manner in Young Neurons. Jackson TC, Manole MD, Kotermanski SE, Clark RS, Kochanek PM. Neuroscience. 2015 Oct 1;305268-78. [Epub Aug 8]

Traumatic Brain Injury Impairs Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Formation and Alters Synaptic Vesicle Distribution in the Hippocampus.Carlson SWYan HMa MLi YHenchir JDixon CE. J Neurotrauma. 2015 Aug 27. [Epub ahead of print]

Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI. Failla MD, Juengst SB, Arenth PM, Wagner AK. Neurorehabil Neural Repair. 2015 Aug 13 [Epub ahead of print].


Tackling the challenges of Clinical Trials for Severe Traumatic Brain Injury in Children: Screening, Phenotyping, and Adapting. Crit Care Med. 2015 Jul;43(7):1544-6.

Repetitive mild traumatic brain injury in the developing brain: effects on long-term functional outcome and neuropathology. Fidan E, Lewis J, Kline AE, Garman RH, Alexander H, Cheng JP, Bondi CO, Clark R, Dezfulian C,Kochanek PMKagan VE, Bayır H. J Neurotrauma. 2015 Jul 27. [Epub ahead of print]

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study. Diamond ML, Ritter AC, Failla MD, Boles JA, Conley YP, Kochanek PM, Wagner AK. Epilepsia. 2015 Jul;56(7):991-1001. 


Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Au AKChen YDu LSmith CM, Manole MDBaltagi SAChu CTAneja RK, Bayır HKochanek PMClark RS. Biochim Biophys Acta. 2015 Sep;1852(9):1902-11. Epub 2015 Jun 11.

20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats.Shaik JS, Poloyac SM, Kochanek PM, Alexander H, Tudorascu DL, Clark RS, Manole MD. J Cereb Blood Flow Metab. 2015 Jun 10. [Epub ahead of print]

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. Diamond ML, Ritter AC, Jackson EK, Conley YP, Kochanek PM, Boison D, Wagner AK. Epilepsia. 2015 Jun 4. [Epub ahead of print]

Alterations in Cholinergic Pathways and Therapetic Strategies Targeting Cholinergic System after Traumatic Brain Injury Injury. Shin SS, Dixon CE. J Neurotrauma. 2015 June 29 [Epub ahead of print]


Management of pediatric traumatic brain injury. Mtaweh H, Bell MJ. Curr Treat Options Neurol. 2015 May;17(5):348.

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.Diamond ML, Ritter AC, Jackson EK, Conley YP, Kochanek PM, Boison D, Wagner AK. Epilepsia. 2015 Jun 4. doi: 10.1111/epi.13044. [Epub ahead of print]

Socioeconomic factors associated with outcome after cardiac arrest in patients under the age of 65. Uray T, Mayr FB, Fitzgibbon J, Rittenberger JC, Callaway CW, Drabek T, Fabio A, Angus DC,Kochanek PM, Dezfulian C. Resuscitation. 2015 May 21;93:14-19. doi: 10.1016/j.resuscitation.2015.04.032. [Epub ahead of print]

Schwann Cells Metabolize Extracellular 2',3'-cAMP to 2'-AMP.Verrier JD, Kochanek PM, Jackson EK. J Pharmacol Exp Ther2015 May 21. pii: jpet.115.225219. [Epub ahead of print]


Posttraumatic Brain Injury Cognitive Performance Is Moderated by Variation Within ANKK1 and DRD2 Genes.Failla MD, Myrga JM, Ricker JH, Dixon CE, Conley YP, Wagner AK. J Head Trauma Rehabil. 2015 Apr 29. [Epub ahead of print]

Chronic Histopathological and Behavioral Outcomes of Experimental Traumatic Brain Injury in Adult Male Animals. Osier ND, Carlson SW, DeSana A, Dixon CE.J Neurotrauma. 2015 Apr 15. [Epub ahead of print]

Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM; THAPCA Trial Investigators. N Engl J Med. 2015 May 14;372(20):1898-908.  [Epub ahead of print Apr 25]

Traumatic Brain Injury Impairs SNARE Complex Formation and Alters Synaptic Vesicle Distribution in the Hippocampus. Carlson SW, Yan HQ, Ma X, Li Y, Henchir JJ, Dixon CE.J Neurotrauma. 2015 Apr 29. [Epub ahead of print]

Evaluation of Electronic Medical Record Vital Sign Data Versus a Commercially Available Acuity Score in Predicting Need for Critical Intervention at a Tertiary Children's Hospital. da Silva YS, Fiedor Hamilton M, Horvat C, Fink EL, Palmer F, Nowalk AJ, Winger DG, Clark RS. Pediatr Crit Care Med. 2015 Apr 21. [Epub ahead of print]

20-HETE is associated with unfavorable outcomes in subarachnoid hemorrhage patients. Donnelly MK, Crago EA, Conley YP, Balzer JR, Ren D, Ducruet AF,Kochanek PM, Sherwood PR, Poloyac SM. J Cereb Blood Flow Metab. 2015 Apr 29. 

Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. Willyerd FA, Empey P, Philbrick A, Ikonomovic M, Puccio AM, Kochanek PM, Okonkwo DO, Clark R. J Neurotrauma. 2015 Apr 19. [Epub ahead of print]

Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children. Newell E, Shellington DK, Simon DW, Bell MJ, Kochanek PM, Feldman K, Bayir H, Aneja RK, Carcillo JA, Clark RS. Pediatric Crit Care Med. 2015 Apr 6 [Epub ahead of print.]

Detection of PHLPP1α/β in Human and Mouse Brain by Different Anti-PHLPP1 Antibodies. Jackson TC, Bayir H, Ikonomivic MD, Janesko-Feldman K, Mi Z, Gao T, Jackson EK, Kochanek PM. Sci Rep. Apr 1;5:9377.


Progesterone for neuroprotection in pediatric traumatic brain injury. Robertson CL, Fidan E, Stanely RM, Noje C, Bayir H. Pediatr Crit Car Med. 2015 Mar;16:236-44.

Targeted Temperature Management in Pediatric Central Nervous System Disease.Newmyer R, Mendelson J, Pang D, Fink EL.Curr Treat Options Pediatr. 2015 Mar 1;1(1):38-47.


Serum D-dimer concentrations are increased after pediatric traumatic brain injury.Berger RP, Fromkin J, Rubin P, Snyder J, Richichi R, Kochanek P. J Pediatr. 2015 Feb;166(2):383-8.

Emerging therapies in traumatic brain injury. Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bayir H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE. Semin Neurol. 2015 Feb; 35(1):83-100.

It might be time to let cooler heads prevail after mild traumatic brain injury or concussion. Kochanek PM, Jackson TC, Exp Neurol. 2015 Feb 27. [Epub ahead of print]

Patterns of multiorgan dysfunction after pediatric drowning. Mtaweh H, Kochanek PM. Carcillo JA, Bell MJ, Fink EL. Resuscitation. 2015 May, 90:91-6.  [Epub ahead of print Feb 19] 

Visual Priming Enhances the Effects of Nonspatial Cognitive Rehabilitation Training on Spatial Learning after Experimental Traumatic Brain Injury.  Edwards CM, Kumar K, Koesarie K, Brough E, Ritter AC, Brayer SW, Thiels E, Skidmore ER, Wagner AK. Neurorehabil Neural Repair. 2015 Feb 9 [Epub ahead of print].


The Nuclear Splicing Factor RNA Binding Motif 5 promotes Caspase Activation in Human Neuronal Cells, and Increases after Traumatic Brain Injury in MIce. Jackson TC, Du L, Janesko-Feldman K, Vagni VA, Dezfulian C, Poloyac SM, Jackson EK, Clark RS, Kochanek PM. J Cereb Blood Flow Metab, 2015 Jan 14 [Epub ahead of print].

Effect of Administration of Neuromuscular Blocking Agents in Children with Severe Traumatic Brain Injury on Acute Complication Rates and Outcomes: A Secondary Analysis from a Randomized, Controlled Trial of Therapeutic Hypothermia. Chin KH, Bell MJ, Wisniewski SR, Goundappa BG, Kochanek PM, Beers SR, Brown SD, Adelson PD: for the Pediatric Traumatic Brain Injury Consortium: Hypothermia Investigators. 2015 Jan 16 [Epub ahead of print].

Neuroprotective effects of collagen matrix in rats after traumatic brain injury. Shin SS, Grandi R, Henchir J, Yan HQ, Badylak SF, Dixon CE. Restor Neurol Neurosci. 2015 Jan 26 [Epub ahead of print].

The Influence of Genetic Variants on Striatal Dopamine Transporter and D2 Receptor Binding after TBI. Wagner AK, Scanlon JM, Becker CR, Ritter AC, Niyonkuru C, Dixon CE, Conley YP, Price JC. J Cereb Blood Flow Metab. 2015 Jan;35(1):166.

Progesterone for Neuroprotection in Pediatric Traumatic Brain Injury. Robertson CL, Fidan E, Stanely RM, Noje C, Bayir H. Pediatr Crit Care Med. 2015 Jan 9 [Epub ahead of print].

Divergent long-term consequences of chronic treatment with haloperidol, risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits. Phelps TI, Bondi CO, Ahmed RH, Olugbade YT, Kline AE. J Neurotrauma. 2015 Apr 15;32(8):590-7. . Epub 2015 Jan 8.