2014 Publications

Articles are listed in the order they are e-published.


Bayir H, Yildiz I.The importance of platelet markers on hospital mortality in intensive care unit patients.J Crit Care. 2014 Dec 3.[Epub ahead of print]

Harun RGrassi CMMunoz MJTorres GEWagner AK.Neurobiological model of stimulated dopamine neurotransmission to interpret fast-scan cyclic voltammetry data.Brain Res. 2014 Dec 16. [Epub ahead of print]

Kumar RGDiamond MLBoles JABerger RP, Tisherman SKochanek PMWagner AK.Acute CSF Interleukin-6 Trajectories after TBI: Associations with Neuroinflammation, Polytrauma, and Outcome.Brain Behav Immun. 2014 Dec 30. [Epub ahead of print]

Osier NCarlson SW, DeSana AJDixon CE.Chronic Histopathological and Behavioral Outcomes of Experimental Traumatic Brain Injury in Adult Male Animals.J Neurotrauma. 2014 Dec 9. [Epub ahead of print]


Cheng JP, Leary JB, Sembhi A, Edwards CM, Bondi CO, Kline AE.5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. Brain Res2015 Nov 21. [Epub ahead of print] 

Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE.Found in translation: Understanding the biology and behavior of experimental traumatic brain injury. Neurosci Biobehav Rev2015 Nov;58:123-46. 

Berger RP, Fromkin J, Rubin P, Snyder J, Richichi R, Kochanek P.Serum D-Dimer Concentrations Are Increased after Pediatric Traumatic Brain Injury.J Pediatr. 2014 Nov 20.[Epub ahead of print]

Drabek T, Kochanek PM.Improving Outcomes from Resuscitation: From H-H to TH to H2.Circulation. 2014 Nov 3.[Epub ahead of print]

Wiley CA, Bonneh-Barkay D, Dixon CE, Lesniak A, Wang G, Bissel SJ, Kochanek PM.Role for mammalian chitinase 3-like protein 1 in traumatic brain injury.Neuropathology. 2014 Nov 7. [Epub ahead of print]

Ji J, Baart S, Vikulina AS, Clark RS, Anthonymuthu TS, Tyurin VA, Du L, St Croix CM, Tyurina YY, Lewis J, Skoda EM, Kline AE, Kochanek PM, Wipf P, Kagan VE, Bayır H.Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion.J Cereb Blood Flow Metab. 2014 Nov 19.  [Epub ahead of print]

Drabek T, Wilson CD, Janata A, Stezoski JP, Janesko-Feldman K, Garman RH, Tisherman SA, Kochanek PM.Unique Brain Region-Dependent Cytokine Signatures After Prolonged Hypothermic Cardiac Arrest in Rats.Ther Hypothermia Temp Manag. 2014 Nov 25. [Epub ahead of print]

Newell EA, Exo JL, Verrier JD, Jackson TC, Gillespie DG, Janesko-Feldman K, Kochanek PM, Jackson EK.2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors.Brain Res. 2014 Nov 3. [Epub ahead of print]


Phelps TI, Bondi CO, Ahmed RH, Olugbade YT, Kline AE. Divergent long-term consequences of chronic treatment with haloperidol, risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits. J Neurotrauma, 2014 Oct 2 [Epub ahead of print.]

Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP; Pediatric Guidline Adherence and Outcomes Study.Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury.Crit Care Med, 2014 Oct;42(10)2258-66.


Trakas EV, Fink ELSerum biomarkers of brain injury: a call for collaboration. Pediatr Crit Care Med. 2014 Sep; 15(7):672-3.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators Network and Australia and New Zealand Intensive Care Society Investigators. Understanding the global epidemiology of pediatric critical illness: the power, pitfalls, and practicallities of point prevalence studies. Pediatr Crit Care Med. 2014 Sep; 15(7):660-66.

Zou H, Hurwitz M, Fowler L, Wagner AK. Abbreviated levetiracetam treatmen effects on behavioral and histological outcomes after experimental TBI. Brain Inj. 2015;29(1):78-85 

Brayer SW, Ketcham S, Zou H, Hurwitz M, Henderson C, Fuletra J, Kumar K, Skidmore E, Thiels E, Wagner AKDeveloping a clinically relevant model of congnitive training after experimental traumatic brain injury.Neurorehabil Neural Repair. 2014 Sep 19. [Epub ahead of print.]

Gao W, Lu C, Kochanek PMBerger RPSerum amyloid A is increased in children with abusive head trauma a gel-based proteomic analysis. Pediatr Res. 2014 Sep;76(3)280-6.

Santarsieri M, Kumar RG, Kochanek PM, Berga S, Wagner AKVariable neuroendocrin-immune dysfunction i individuals with unfavorable outcome after severe traumatic brain injury. Brain Behave Immun. 2014 Sep 16 [Epub ahead of print]


Shin SSDixon CE, Okonkwo DO, Richardson RM. Neurostimulation for traumatic brain injury. J Neurosurg.2014 Aug 29: 1-13. [Epub ahead of print]

Carlson SWMadathil SKSama DMGao XChen JSaatman KE.Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury.J Neuropathol Exp Neurol. 2014 Aug;73(8):734-46.

Wagner AKScanlon JMBecker CRRitter ACNiyonkuru CDixon CEConley YPPrice JC.The influence of genetic variants on striatal dopamine transporter and D2 receptor binding after TBI.J Cereb Blood Flow Metab.2014 Aug;34(8):1328-39. doi: 10.1038/jcbfm.2014.87. [Epub ahead of print]

Sanchez-de-Toledo JChrysostomou CMunoz RLichtenstein SSao-Avilés CAWearden PDMorell VO,Clark RSToney NBell MJ.Cerebral regional oxygen saturation and serum neuromarkers for the prediction of adverse neurologic outcome in pediatric cardiac surgery.Neurocrit Care. 2014 Aug;21(1):133-9.

Da Silva YS, Horvat CM, Dezfulian C.Thiamine Deficiency as a Cause of Persistent Hyperlactatemia in a Parenteral Nutrition-Dependent Patient.JPEN J Parenter Enteral Nutr. 2014 Aug 5. [Epub ahead of print]


Fink EL, Houtrow A. A new era of personalized rehabilitation in the PICU. Pediatr Crit Care Med. 2014 Jul; 15(6)571-2.

Trzeciak S, Glaspey LJ, Dellinger RP, Duflinger P, Anderson K, Dezfulian C, Roberts BW. Chansky ME, Parrillo JE, Hollenberg SM. Randomized controlled trial of inhaled nitric oxide for the treatment of microcirculatory dysfunction in patients with sepsis. Crit Care MEd, 2014 Jul 30. [Epub ahead of print.]

Wagner AK.A Rehabilomics framework for personalized and translational rehabilitation research and care for individuals with disabilities: Perspectives and considerations for spinal cord injury.J Spinal Cord Med. 2014 Jul 16. [Epub ahead of print]

Failla MDKumar RG, Peitzman ABConley YPFerrell REWagner AK.Variation in the BDNF Gene Interacts With Age to Predict Mortality in a Prospective, Longitudinal Cohort with Severe TBI.Neurorehabil Neural Repair.2015 Mar-Apr;29(3):234-46.. [Epub Jul 2014]

Monaco CMGebhardt KMChlebowski SMShaw KE, Cheng JPHenchir JJZupa MFKline AE.A combined therapeutic regimen of buspirone and environmental enrichment is more efficacious than either alone in enhancing spatial learning in brain-injured pediatric rats.J Neurotrauma. 2014 Dec 1;31(23):1934-41 [Epub July 2014]

Vavilala MSKernic MAWang JKannan NMink RBWainwright MSGroner JIBell MJGiza CCZatzick DFEllenbogen RGBoyle LNMitchell PHRivara FP;for the Pediatric Guideline Adherence and Outcomes Study.Acute Care Clinical Indicators Associated With Discharge Outcomes in Children With Severe Traumatic Brain Injury.Crit Care Med. 2014 Oct;42(10):2258-66. [Epub July 2014]

Amoscato AASparvero LJHe RRWatkins SBayir HKagan VE.Imaging mass spectrometry of diversified cardiolipin molecular species in the brain.Anal Chem. 2014 Jul 1;86(13):6587-95. 

Jackson EKCheng DVerrier JDJanesko-Feldman KKochanek PM.Interactive Roles of CD73 and Tissue Non-Specific Alkaline Phosphatase in the Renal Vascular Metabolism of 5'-AMP.Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F680-5. [Epub July2014]


Tress EEClark RSFoley LM, Alexander HHickey RWDrabek TKochanek PMManole MD.Blood brain barrier is impermeable to solutes and permeable to water after experimental pediatric cardiac arrest.Neurosci Lett. 2014 Jun 14;578C:17-21.

Uray TKochanek PM.Finding a faster and safer way to "catch a cold" after cardiac arrest: We may be getting closer.Resuscitation. 2014 Sep;85(9):1131-3. [Epub Jul 2014]

Juengst SB, Kumar RG, Arenth PM, Wagner AKExploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury. Brain Behav Immun.2014 Oct;41:134-43 [Epub Jun 2014]

Wagner AK, Sowa G.Rehabilomics Research: A Model for Translational Rehabilitation and Comparative Effectiveness Rehabilitation Research.Am J Phys Med Rehabil. 2014 Oct;93(10):913-6.  [Epub Jun 4]

Au AK, Bell MJ.Severe postoperative hyponatremia after pediatric intracranial tumor surgery-is this preventable?*. Pediatr Crit Care Med. 2014 Jun;15(5):497-8.

Walko TD 3rd, Bola RA, Hong JD, Au AKBell MJ, Kochanek PM, Clark RS, Aneja RK.Cerebrospinal Fluid Mitochondrial DNA: A Novel DAMP in Pediatric Traumatic Brain Injury.Shock. 2014 Jun;41(6):499-503.

Yousef KMBalzer JRCrago EAPoloyac SMSherwood PR.Transcranial regional cerebral oxygen desaturation predicts delayed cerebral ischaemia and poor outcomes after subarachnoid haemorrhage: A correlational study.Intensive Crit Care Nurs. 2014 Jun 2.


Wagner AK, Scanlon JM, Becker CR, Ritter AC, Niyonkuru C, Dixon CE, Conley YP, Price JC.The influence of genetic variants on striatal dopamine transporter and D2 receptor binding after TBI.J Cereb Blood Flow Metab.2014 May 21.

Lindberg DM, Berger RP, Reynolds MS, Alwan RM, Harper NS; Examining Siblings To Recognize Abuse (ExSTRA) Investigators.Yield of Skeletal Survey by Age in Children Referred to Abuse Specialists.J Pediatr.2014 Mar 12.[Epub ahead of print]

Jackson EK, Gillespie DG, Mi Z, Cheng D, Bansal R, Janesko-Feldman KKochanek PM.Role of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase in the Renal 2',3'-cAMP-Adenosine Pathway.Am J Physiol Renal Physiol. 2014 May 7. [Epub ahead of print]

Gallek MJ, Alexander SA, Crago E, Sherwood PR, Klamerus M, Horowitz MB, Poloyac SM, Conley Y.Endothelin-1 Gene Polymorphisms Influence Cerebrospinal Fluid Endothelin-1 Levels Following Aneurysmal Subarachnoid Hemorrhage.Biol Res Nurs. 2014 May 22.


Murnin MR, Sonder P, Janssens GN, Henry CL, Polderman KH, Rittenberger JC, Dezfulian C; Post Cardiac Arrest Service.Determinants of heat generation in patients treated with therapeutic hypothermia following cardiac arrest.J Am Heart Assoc. 2014 Apr 29;3(3):e000580.

Tyurina YY, Poloyac SS, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW, Mohammadyani D,Klein-Seetharaman J, Jackson TCKochanek PM, Pitt BR, Greenberger JS, Vladimirov YA, Bayır H, Kagan VE. A mitochondrial pathway for biosynthesis of lipid mediators.Nat Chem. 2014 Jun;6(6):542-52. [Epub ahead of print.]

Foster KA, Recker M, Lee P, Bell MJ, Tyler-Kabara E.Factors Associated with Hemispheric Hypodensity after Subdural Hematoma following Abusive Head Trauma in Children.J Neurotrauma. 2014 Apr 2. [Epub ahead of print]

Drabek T, Foley LM, Janata A, Stezoski J, Kevin Hitchens T, Manole MDKochanek PM.Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI.Resuscitation. 2014 Apr 12. [Epub ahead of print]

Diamond ML, Ritter AC, Failla MD, Boles JA, Conley YP, Kochanek PMWagner AK.IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study.Epilepsia. 2014 Apr 22. [Epub ahead of print]

Shein S, Shellington DK, Exo J, Jackson TC, Wisniewski SR, Jackson E, Vagni VABayir HClark RDixon CEJanesko KLKochanek PMHemorrhagic shock shifts the serum cytokine profile from pro-to anti-inflammatory after experimental traumatic brain injury in mice.J Neurotrauma. 2014 Apr 28. [Epub ahead of print]


Fink EL.Minding the brain.Pediatr Crit Care Med. 2014 Mar;15(3):270-1.

Begum G, Yan HQ, Li L, Singh A, Dixon CE, Sun D.Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury.J Neurosci. 2014 Mar 5;34(10):3743-55.

Jiang J, Bakan A, Kapralov AA, Ishara Silva K, Huang Z, Amoscato AA, Peterson J, Krishna Garapati V, Saxena S, Bayir H, Atkinson J, Bahar I, Kagan VE.Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: mitochondria-targeted imidazole-substituted fatty acids.Free Radic Biol Med. 2014 Mar 12;71C:221-230.  2014 Jun;71:221-30. [Epub March 2014]

Walko TD 3rd, Bola RA, Hong JD, Au AK, Bell MJ, Kochanek PM, Clark, RS, Aneja RK. Cerebrospinal fluid mitochondrial DNA - A Novel DAMP in Pediatric Traumatic Brain Injury. Shock  Jun;41(6):499-503. [Epub March 2014].

Simon DW, Clark RS, Watson RR. No pain, no gain in pediatric sepsis? Pediatr Crit Care Med. 2014 Mar; 15(3):264-6.

Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Richichi R, Panigrahy A, Callaway CW, Bell MJ, Kochanek PM. Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest. Crit Care Med. 2014 Mar;42(3)664-74.

Stoyanovsky DA, Sparvero LJ, Amoscato AA, He RR, Watkins S, Pitt BR, Bayir H, Kagan V. Improved spatial resolution of marix-assosiated laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid. Rapid Commun Mass Spectrom. 2014 Mar;28(5):403-412.


Drabek T, Janata A, Wilson CD, Stezoski J, Janesko-Feldman KTisherman SA, Foley LM, Verrier JD,Kochanek PM. Minocycline attenduates brain tissue levels of TNF-α produced by neurons after prolonged hypothermic cardiac arrest in rats. Resuscitation. 2014 Feb;85(2):284-91.

Juengst SB, Kumar RG, Failla MD, Goyal A, Wagner AKAcute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury. J Head Trauma Rehabil. 2015 May-Jun;30(3):207-18.  [Epub Feb 2015]

Zelnick L, Morrison LJ, Devlin SM, Bulger EM, Brasel KJ, Sheehan K, Minei JP, Kerby JD, Tisherman SA, Rizoli S, Karmy-Jones R, can Heest R, Newgard CD. Addressing the challenges of obtaining functional outcomes in traumatic brain injury research: missign data patterns, timing of follow-up, and three prognostic models. J Neurotrauma 2014 Jun 1;31(11):1029-38. [Epub Feb 2014].

Bondi CO, Klitsch KC, Leary J, Kline AEEnvironmental enrichment as a viable neurorehabilitation strategy for experimental traumatic brain injury. J Neurotrauma. 2014 May 15;31(10):873-88. [Epub Feb 2014].

Callaway CWStudying community consultation in exception from informed consent trials*. Crit Care Med. 2014 Feb;42(2):451-3.

Suffoletto B, Hu J, Guyette M, Callaway CFactors contributing to emergency department care within 30 days of hopsital discharge and potential ways to prevent it: Differences in perspectives of patients, caregivers, and emergency physicians. J Hosp Med. 2014 May;9(5):315-9. [Epub Feb 2014].

Santarsieri M, Niyonkuru C, McCullough EH, Dobos JA, Dixon CE, Berga SL, Wagner AKCerebrospinal fluid cortisol and progesterone profiles and outcomes prognostication after severe traumatic brain injury. J Neurotrauma. 2014 Apr 15;31(8):699-712. [Epub Feb 2014]

Tisherman SAIf some hypothermia is good, more hypothermia must be better, right?* Crit Care Med. 2014 Feb;42(2):489-90.

Janata A, Magnet IA, Uray T, Stezoski JP, Janesko-Feldman K, Tisherman SA, Kochanek PM, Drabek T.Regional TNFα Mapping in the brain reveals the striatum as a neuroinflammatory target after ventricular fibrillation cardiac arrest. Resuscitation 2014 May;85(5):694-701.  [Epub Feb. 2014]


Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP.Interleukin 6 and apolipoprotein e as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care.2014 Jan;23(1):49-57.

Kochanek PMJackson TCWill the next breakthrough for neuroprotection after cardiac arrest come out of thin air? Shock. 2014 Jan;41(1):85-6.

Mtaweh H, Smith R, Kochanek PM, Wisniewski SR, Fabio A, Vavilala MS, Adelson PD, Toney NA, Bell MJ.Energy expenditure in children after severe traumatic brain injury. Pediatr Crit Care Med.  2014 Mar;15(3):242-9. [Epub Jan. 2014]

Bondi CO, Cheng JP, Tennant HM, Monaco CM, Kline AEOld dog, new tricks: the attentional set-shifting test as a novel cognitive behavioral task after controlled cortical impact injury. J Neurotrauma. 2014 May 15;31(10):926-37. [Epub Jan. 2014]

Lin HW, Gresia VL, Stradecki HM, Alekseyenko A, Dezfulian C, Neumann JT, Dave KR, Perz-Pinzon MA.Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. J Cereb Blood Flow Metab. 2014 Apr;34(4):613-20.  [Epub Jan. 2014]

Kochanek PM, Callaway CWTargeting therapeutic hypothermia in neonatal resuscitation and beyond: It is time to phenotype. Resuscitation. 2014 Apr;85(4):458-9. [Epub Jan 2014]

Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP. Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care 2014 Jan;23(1):49-57.

Diaz-Arrastia R, Kochanek PM, Bergold P, Kenney K, Marx CE, Grimes CJ, Loh LT, Adam LT, Oskvig D,Curley KC, Salzer W.Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup.J Neurotrauma. 2014 Jan 15;31(2):135-58.