2013 Publications

Articles are listed in the order they are e-published.


Santarsieri M, Niyonkuru C, McCullough E, Dobos J, Dixon CE, Berga S, Wagner AK M D.CSF Cortisol and Progesterone Profiles and Outcomes Prognostication after Severe TBI. J Neurotrauma. [Epub Dec. 2013]

Yan HQ, Shin SS, Ma X, Li Y, Dixon CE. Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus. Brain Res. [Epub Dec. 2013].

Tyurina YY, Donmingues RM, Tyurin CA, Michel E, Dominguez P, Amoscato AA, Bayir H, Kagan VE. Characterization of cardiolipins and their oxidation products by LC-MS analysis. Chem Phys Lipids. [Epub Dec. 2013]

Kagan VE, Chu CT, Tyurina YY, Cheikhi A, Bayir H.Cardiolipin asymmetry,oxydaton and signaling. Chem Phys Lipids. [Epub Dec. 2013]

Tisherman SA. Salvage techniques in traumatic cardiac arrest: thoracotomy, ectracorporeal life support, and therapeutic hypothermia. Curr Opin Crit Care. 2013 Dec; 19(6):594-598.


Manole MD, Kochanek PM, Bayir H, Alexander H, Dezfulian C, Fink EL, Bell MJ, Clark RS. Brain tissue oxygenation monitering identifies cortical hypoxia and thalamic hyperoxia after experimental pediatric cardiac arrest. Pediatr Res. [Epub Nov. 2013]

Sanchez-de-Toledo J, Chrysostomou C, Munoz R, Lichtenstein S, Sao-Aviles CA, Wearden PD, Morell VO, Clark RS, Toney N, Bell MJ. Cerebral regional oxygen saturation and serum neuromarkers for the prediction of adverse neurologic outcome in pediatric cardiac surgery. Neurocrit Care. [Epub Nov. 2013]

Cleve WV, Kernic MA, Ellenbogen RG, Wang J, Zatzick DF, Bell MJ, Wainwrifht MS, Groner JL, Mink RB, Giza CC, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS: PEGASUS (Pediatric Guideline Adherence and Outcomes) Project. National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery. 2013 NoV; 73(5):746-52.

Reynolds JC, Frisch A, Rittenberger JC, Callaway CWDuration of resuscitation efforts and functional outcome after out-of-hospital cardaic arrest: when should we change to novel therapies? Circulation. [Epub Nov 2013]

Reynolds JC, Rittenberger JC, Callaway CWThe Post Cardiac Arrest Service. Patterns of organ donation among resusitated patients at a regional cardiac arrest center. Resuscitation. [Epub Nov 2013]

Tisherman SA, Alam HB, Chiu WC, Emlet LL, Grossman MD, Luchette FA, Marcolini EG, Mayglothling JA. Surgical critical care training for emergency physicians: curriculum recommendations. J Am Coll Surg. 2013 Nov;217(5):954-959. e3


Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SMSoluble Epoxide Hydrolase Inhibitor trans-4-[4-(3-Adamantan-1-yl-ureido)- cyclohexyloxy]-benzoic Acid (t-AUCB) is Neuroprotective in Rat Model of Ischemic Strike. Am J Physiol Circ Physiol. [Epub Oct. 2013]

Kochanek PM, Bell MJ. Making  an IMPACT in traumatic brain injury research. Lancet Neurol. pii: S1474-4422(13)70245-X. [Epub Oct. 2013]

Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Richichi R, Panigrahy A, Callaway C, Bell MJ, Kochanek PMSerum Biomarkers of Brain Injury to Classify Outcome After Pediatric Cardiac Arrest. Crit Care Med. [Epub Oct. 2013] 

Cousar JL, Conley YP, Willyerd FASarnaik AA, Puccio AM, Empey PE, Kochanek PM, Bell MJ, Okonkwo DO, Clark RSInfluence of ATP-binding Cassette Polymorphisms on Neurological Outcome After Traumatic Brain Injury. Neurocrit Care. 2013 Oct;19(2): 192-8.

Berger PR, Parks S, Fromkin J, Rubin P, Pecora PJ. Assessing the Accuracy of the International Classification of Diseases Codes to Identify Abusive Head Trauma: A Feasibility Study. Inj Prev. [Oct. 2013]


Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayır H, Kagan VE. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol. 15(10):1197-205, Oct. 2013 [Epub Sept. 2013]

Jackson TC, Verrier JD, Drabek TJanesko-Feldman K, Gillespie DG, Uray TDezfulian CClark RSBayir H, Jackson EK, Kochanek PMPharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) is Neuroprotective: Differential Effects on Astrocytes. J Pharmacol Exp Ther. [Epub Sept. 2013]

Lindberg DM, Berger RP, Lane WG. PECARN Abdominal Injury Rule Should Exclude Potentially Abused Children. Ann Emerg Med. 62(3):276-7, Sept . 2013.

Mtaweh HBayir H, Kochanek PM, Bell MJEffect of a Single Dose of Propofol and Lack of Dextrose Administration in a Child with Mitochondrial Disease: A Case Report. J Child Neurol. [Epub Sept. 2013]

Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens KT, Graham SH, Hwang SH, Hammock BD, Poloyac SMSoluble Epoxide Hydrolase Inhibitor trans-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic Acid (t-AUCB) is Neuroprotective in Rat Model of Ischemic Stroke. Am J Physiol Heart Circ Physiol. [Epub Sept. 2013]


Diaz-Arrastia R, Kochanek PM, Bergold P, Kenney K, Marx C, Grimes J, Loh Y, Adam G, Oskvig DB, Curley K, Salzer W. Pharmacotherapy of Traumatic Brain Injury: State of the Science and the Road Forward Report of the Department of Defense Neurotrauma Pharmacology Workgroup. Neurotrauma. [Epub Aug. 2013]

Jackson EK, Cheng D, Mi Z, Verrier JD, Janesko-Feldman KKochanek PMRole of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney. Physiol Rep. 20;1(3). pii: e00057, Aug. 2013.

Liu H, Li W, Rose ME, Pascoe JL, Miller TM, Ahmad M, Poloyac SM, Hickey RW, Graham SH. Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. Neurotoxicology.  22;39C:35-44. [Epub Aug. 2013]

Verrier JD, Jackson TC, Gillespie DG, Janesko-Feldman K, Bansal R, Goebbels S, Nave KA, Kochanek PM, Jackson EK.  Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway. Glia. doi: 10.1002/glia.22523. [Epub Aug. 2013]


Berger RP, Zolotor AJ. Is there an association between physical punishment in childhood and physical health in adulthood? Pediatrics. 132(2):e500-1. Aug. 2013. [Epub Jul. 2013]

Van Cleve W, Kernic MA, Ellenbogen RG, Wang J, Zatzick DF, Bell MJ, Wainwright MS, Groner JI, Mink RB, Giza CC, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS; for the PEGASUS (Pediatric Guideline Adherence and Outcomes) Project. Differences in Medical Therapy Goals for Children With Severe Traumatic Brain Injury-An International Study. Pediatr Crit Care Med. [Epub Jul. 2013]

Empey PE, de Mendizabal NV, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM; for the Pediatric TBI Consortium: Hypothermia Investigators. Therapeutic Hypothermia Decreases Phenytoin Elimination in Children with Traumatic Brain Injury. Crit Care Med. [Epub Jul. 2013]

Sarnaik SM, Saladino RA, Manole M, Pitetti RA, Arora G, Kuch BA, Orr RA, Felmet KA. Diastolic Hypotension Is an Unrecognized Risk Factor for β-Agonist-Associated Myocardial Injury in Children With Asthma. Pediatr Crit Care Med. 14(6):e273-9, Jul. 2013.

Wagner AKBrayer SW, Hurwitz M, Niyonkuru C, Zou HFailla M, Arenth P, Manole MD, Skidmore E, Thiels E. Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI. Neurobiol Learn Mem. pii: S1074-7427(13)00119-6 [Epub  Jul. 2013]

Early BJ, Huang DT, Callaway CW, Zenati M, Angus DC, Gunn SR, Yealy DM, Unikel D, Billiar TR, Peitzman AB, Sperry JL. Multidisciplinary acute care research organization (MACRO): If you build it, they will come. J Trauma Acute Care Surg. 75(1):106-9. Jul. 2013

Bondi CO, Taha AY, Tock JL, Totah NK, Cheon Y, Torres GE, Rapoport SI, Moghaddam B. Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency. Biol Psychiatry. [Epub Jul 2013]


Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR; and the Multiple Medical Therapies for Pediatric Traumatic Brain Injury Workgroup. Differences in Medical Therapy Goals for Children With Severe Traumatic Brain Injury-An International Study. Pediatr Crit Care Med. [Epub Jul. 2013]

Brockman ECBayır H, Blasiole B, Shein SLFink ELDixon CClark RSVagni VA, Ma L, Hsia CJ, Tisherman SA, Kochanek PM.  Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice. J Cereb Blood Flow Metab.  doi: 10.1038/jcbfm.2013.104. [Epub Jun. 2013]

Deye KP, Berger RP, Lindberg DM; for the ExSTRA Investigators. Occult abusive injuries in infants with apparently isolated skull fractures. J Trauma Acute Care Surg. 74(6):1553-1558. Jun. 2013.

Failla MD, Burkhardt JN, Miller MA, Scanlon JM, Conley YP, Ferrell RE, Wagner AKVariants of SLC6A4 in depression risk following severe TBI. Brain Inj. 27(6):696-706. Jun. 2013.

Goyal A, Failla MD, Niyonkuru C, Amin K, Fabio A, Berger RPWagner AKS100b as a prognostic biomarker in outcome prediction for patients with severe traumatic brain injury. J Neurotrauma. 30(11):946-57. Jun. 2013.

Moreau JF, Fink EL, Hartman ME, Angus DC, Bell MJ, Linde-Zwirble WT, Watson RS. Hospitalizations of Children With Neurological Disorders in the United States. Pediatr Crit Care Med. [Epub Jul. 2013]

Mondello S, Schmid K, Berger RP, Kobeissy F, Italiano D, Jeromin A, Hayes RL, Tortella FC, Buki A. The Challenge of Mild Traumatic Brain Injury: Role of Biochemical Markers in Diagnosis of Brain Damage. Med Res Rev. doi: 10.1002/med.21295. [Epub Jun. 2013]

Niyonkuru C, Wagner AK, Ozawa H, Amin K, Goyal A, Fabio A. Group-Based Trajectory Analysis Applications for Prognostic Biomarker Model Development in Severe TBI: A Practical Example. J Neurotrauma.  30(11):938-45. [Epub Jun. 2013]

Suffoletto B, Miller T, Frisch A, Callaway CEmergency physician recognition of delirium. Postgrad Med J. 2013 Jun 20. [Epub ahead of print]

Salciccioli JD, Cocchi MN, Rittenberger JC, Peberdy MA, Ornato JP, Abella BS, Gaieski DF, Clore J, Gautam S, Giberson T, Callaway CW, Donnino MW. Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients. Resuscitation.  [Epub Jun. 2013]

Sandroni C, Cavallaro F, Callaway CW, Sanna T, D'Arrigo S, Kuiper M, Marca GD, Nolan JP. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 1: Patients not treated with therapeutic hypothermia. Resuscitation.  [Epub Jun. 2013]

Scribano PV, Makoroff KL, Feldman KWBerger RPAssociation of perpetrator relationship to abusive head trauma clinical outcomes. Child Abuse Negl. [Epub Jun. 2013]

Zou HBrayer SW, Hurwitz M, Niyonkuru C, Fowler LE, Wagner AKNeuroprotective, Neuroplastic, and Neurobehavioral Effects of Daily Treatment With Levetiracetam in Experimental Traumatic Brain Injury. Neurorehabil Neural Repair. [Epub Jun. 2013]


Janata A, Drabek T, Magnet IA, Stezoski JPJanesko-Feldman K, Popp E, Garman RH, Tisherman SAKochanek PMExtracorporeal Versus Conventional Cardiopulmonary Resuscitation After Ventricular Fibrillation Cardiac Arrest in Rats: A Feasibility Trial. Crit Care Med. [Epub May 2013]

Tisherman SATargeted temperature management after cardiac arrest: How invasive do we need to be? Resuscitation. [Epub May 2013]

Zhang L, Zhang F, Weng Z, Brown BN, Yan H, Ma XM, Vosler PS, Badylak SF, Dixon CE, Cui XT, Chen J. Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury. Tissue Eng Part A. 2013 Sep;19(17-18):1909-18. [Epub May 2013]

Kim H, Crago E, Kim M, Sherwood P, Conley Y, Poloyac S, Kerr M. Cerebral vasospasm after sub-arachnoid hemorrhage as a clinincal predictor and phenotype for genetic association study. Int J Stroke. 8(8):620-625. [Epub May 2013]


Bell MJ, Kochanek PMPediatric traumatic brain injury in 2012: the year with new guidelines and common data elements. Crit Care Clin. 2013 Apr;29(2):223-38.

Kochanek PM, Berger RP, Fink EL, Au AK, Bayır H, Bell MJ, Dixon CE, Clark RSThe potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care. Front Neurol. 2013 Apr 26; 4:40, 2013.

Lindberg DM, Blood EA, Campbell KA, Laskey AL, Berger RP; Examining Siblings to Recognize Abuse (ExSTRA) Study Group. Predictors of screening and injury in contacts of physically abused children. J Pediatr. 2013 Sep;163(3):730-735.e3. [Epub April 2013]

Liu H, Rose ME, Miller TM, Li W, Shinde SN, Pickrell AM, Poloyac SM, Graham SH, Hickey RW.  COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest. Brain Res. 2013 Jun 26;1519:71-7. [Epub April 2013]

Manole MD, Fink EL. Arterial carbon dioxide tension after cardiac arrest: Too little, too much, or just right? Resuscitation. [Epub April 2013]

Zuccoli G, Panigrahy A, Haldipur A, Willaman D, Squires J, Wolford J, Sylvester C, Mitchell E, Lope LA, Nischal KK, Berger RPSusceptibility weighted imaging depicts retinal hemorrhages in abusive head trauma. Neuroradiology. 2013 Jul;55(7):889-93. [Epub April 2013]


Blasiole BBayır HVagni VAJanesko-Feldman K, Cheikhi A, Wisniewski SR, Long JB, Atkins J, Kagan V, Kochanek PMEffect of Hyperoxia on Resuscitation of Experimental Combined Traumatic Brain Injury and Hemorrhagic Shock in Mice. Anesthesiology 2013 Mar;118(3):649-663.

Garringer J, Niyonkuru C, McCullough E, Loucks TL, Dixon CE, Conley YP, Berga S, Wagner AKImpact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI. J Neurotrauma. [Epub March 2013]

Kochanek PMDixon CE, Shellington DK, Shin SSBayir HJackson E, Kagan V, Yan HQ, Swauger PV, Parks S, Ritzel DV, Bauman RA, Clark R, Garman RH, Bandak F, Ling GS, Jenkins LW. Screening of Biochemical and Molecular Mechanisms of Secondary Injury and Repair in the Brain after Experimental Blast-Induced Traumatic Brain Injury in Rats. J Neurotrauma. [Epub March 2013]

Shaw KE, Bondi CO, Light SH, Massimino LA, McAloon RL, Monaco CMKline AE. Donepezil is Ineffective in Promoting Motor and Cognitive Benefits after Controlled Cortical Impact Injury in Male Rats. J Neurotrauma. [Epub March 2013]

Suffoletto B, Wagner AK, Arenth PM, Calabria J, Kingsley E, Kristan J, Callaway CWMobile Phone Text Messaging to Assess Symptoms After Mild Traumatic Brain Injury and Provide Self-Care Support: A Pilot Study. J Head Trauma Rehabil. [Epub March 2013]

Wagner AK, Zitelli KT. A Rehabilomics focused perspective on molecular mechanisms underlying neurological injury, complications, and recovery after severe TBI. Pathophysiology. [Epub March 2013]


Abrahamson EE, Foley LM, DeKoskey ST, Hitchens TK, Ho CKochanek PM, Ikonomovic MD. Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice. J Cereb Blood Flow Metab. [Epub Feb. 2013]

Berger R, McGinn T. Deciding whether to screen for abusive head trauma: do we need a clinical decision rule?*. Pediatr Crit Care Med. 2013 Feb;14(2):230-1.

Darrah SD, Miller MA, Ren D, Hoh NZ, Scanlon JM, Conley YP, Wagner AKGenetic variability in glutamic acid decarboxylase genes: associations with post-traumatic seizures after severe TBI. Epilepsy Res. 2013 Feb; 103(2-3):180-94.

Guerra-Wallace MM, Casey FL 3rd, Bell MJFink EL, Hickey RW. Hyperoxia and Hypoxia in Children Resuscitated From Cardiac Arrest. Pediatr Crit Care Med. [Epub Feb. 2013]

Heidemann SM, Holubkov R, Meert KL, Dean JM, Berger JBell M, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Willson DF, Nicholson C, Carcillo J; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Baseline Serum Concentrations of Zinc, Selenium, and Prolactin in Critically Ill Children. Pediatr Crit Care Med. [Epub Feb. 2013]

Shin SS, Bales JW, Yan HQ, Kline AEWagner AK, Lyons-Weiler J, Dixon CE. The Effect of Environmental Enrichment on Substantia Nigra Gene Expression after Traumatic Brain Injury in Rats. J Neurotrauma. [Epub Feb. 2013]

Thampatty BP, Klamerus MM, Oberly PJ, Feldman KLBell MJ, Tyler-Kabara EC, Adelson PD, Clark RS, Kochanek PMPoloyac SM. Hypothermia Decreases Cerebrospinal Fluid Asymmetric Dimethylarginine Levels in Traumatic Brain Injury Children. Pediatr Crit Care Med. [Epub Feb. 2013]


Adelson PD, Fellows-Mayle W, Kochanek PMDixon CEMorris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat. Childs Nerv Syst. 2013 Jan;29(1):43-53.

Jackson TC, Verrier JD, Kochaenk PMAnthraquinone-2-sulfonic acid (AQ2S) is A Novel Neurotherapeutic Agent. Cell Death Dis.  2013 Jan;10;4:e451.

Matthews M, Bondi C, Torres G, Moghaddam B. Reduced presynaptic dopamine activity in adolescent dorsal striatum. Neuropsychopharmacology. [Epub Jan. 2013]

Monaco CM, Mattiola VV, Folweiler KA, Tay JK, Yelleswarapu NK, Curatolo LM, Matter AM, Cheng JPKline AEEnvironmental enrichment promotes robust functional and histological benefits in female rats after controlled cortical impact injury. Exp Neurol. [Epub Jan. 2013]

Tavarez MM, Saladino RA, Gaines BA, Manole MDPrevalence, clinical features and management of pediatric magnetic foreign body ingestions. J Emerg Med. 2013 Jan;44(1):261-8.

Vavilala MS, Kernic MA, Rivara FP, Zatzick DF, Bell MJ, Wainwright M, Groner JI, Giza CC, Mink R, Ellenbogen R, Boyle L, Mitchell P, Kannan N. Triage of Children with Moderate and Severe Traumatic Brain Injury to Trauma Centers. J Neurotrauma. [Epub Jan. 2014]