2012 Publications


Bell MJ, Pineda JA, Vavilala MS, Wainwright MS, Doctor A, Stanley R, Thompson AE. Neurocritical Care Research Networks-Pediatric Considerations. Neurocrit Care. 2012 Dec, 17:468-9; author reply 470.

Topjian AA, Berg RA, Bierens JJ, Branche CM, Clark RS, Friberg H, Hoedemaekers CW, Holzer M, Katz LM, Knape JT, Kochanek PM, Nadkarni V, van der Hoeven JG, Warner DS. Brain Resuscitation in the Drowning Victim. Neurocrit Care. 2012 Dec;17(3):441-67.

Liu H, Sarnaik SM, Manole MD, Chen Y, Shinde SN, Li W, Rose M, Alexander H, Chen J, Clark RS, Graham SH, Hickey RW. Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival. Resuscitation. 2012 Dec;83(12):1491-6.

Kochanek PMBayır HOptimizing oxygenation and ventilation after cardiac arrest in "little adults."Resuscitation. 2012 Dec, 8:1425-6.


Su E, Bell MJKochanek PM, Wisniewski SR, Bayir HClark RS, Adelson PD, Tyler-Kabara EC, Janesko-Feldman KLBerger RP.  Increased CSF Concentrations of Myelin Basic Protein After TBI in Infants and Children: Absence of Significant Effect of Therapeutic Hypothermia.  Neurocritical Care. 2012 Aug 14. 2012 Nov;10(5):383-91.

Cheng JP, Shaw KE, Monaco CM, Hoffman AN, Sozda CN, Olsen AS, Kline AEA Relatively Brief Exposure to Environmental Enrichment after Experimental Traumatic Brain Injury Confers Long-Term Cognitive Benefits. J Neurotrauma. 2012 Nov 20, 29:2684-8.

Shein SLBell MJ, Su E, Kochanek PM, Exo J. Intracranial monitoring and continuous data collection. Crit Care Med. 2012 Nov, 40:3115-6.


Alam HB, Pusateri AE, Kindzelski A, Egan D, Hoots K, Andrews MT, Rhee P, Tisherman S, Mann K, Vostal J,Kochanek PM, Scalea T, Deal V, Sheppard F, Sopko G; and the HYPOSTAT workshop participants.Hypothermia and hemostasis in severe trauma: A new crossroads workshop report. J Trauma Acute Care Surg. 2012 Oct, 73:809-817.

Su E, Shoykhet M, Bell MJSevere hypernatremia in a hospitalized child: munchausen by proxy. Pediatr Neurol. 2010 Oct,43(4):270-3.

Jackson EK, Cheng D, Mi Z, Verrier JD, Janesko-Feldman KKochanek PMRole of A1 receptors in renal sympathetic neurotransmission in the mouse kidney. Am J Physiol Renal Physiol. 2012 Oct;303: F1000-5.

Shein SLBell MJKochanek PM, Tyler-Kabara EC, Wisniewski SR, Feldman K, Makoroff K, Scribano PV,Berger RPRisk Factors for Mortality in Children with Abusive Head Trauma. J Pediatrics. 2012 Oct, 161:716-722

Ji JKline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JPAlexander HClark RSBKochanek PM, Wipf P, Kagan VE, Bayir HLipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nature Neuroscience. 2012 Oct,15:1407-13.


Stippler M, Ortiz V, Adelson PD, Chang YF, Tyler-Kabara EC, Wisniewski SR, Fink ELKochanek PM, Brown SD,Bell MJBrain tissue oxygen monitoring after severe traumatic brain injury in children: relationship to outcome and association with other clinical parameters. J Neurosurg Pediatr. 2012 Sep 14. [Epub ahead of print].

Shein SL, Reynolds TQ, Gedela S, Kochanek PMBell MJTherapeutic Hypothermia for Refractory Status Epilepticus in a Child with Malignant Migrating Partial Seizures of Infancy and SCN1A Mutation: A Case Report.Therapeutic Hypothermia and Temperature Management. 2012 Sept 2: 144-49.


Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K,Xu M, Wisniewski SR, Jenkins LWClark RS, Kochanek PMSevere Brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice. J Neurotrauma. 2012 Aug 10,29:2192-208

Kirk KA, Shoykhet M, Jeong JH, Tyler-Kabara EC, Henderson MJ, Bell MJFink ELDysautonomia after pediatric brain injury. Dev Med Child Neurol. 2012 Aug,54:759-64.

Drabek T, Němec J. Anesthetic management of electrophysiological procedures for heart failure. Int Anesthesiol Clin. 2012 Summer,50:22-42.


Au AK, Aneja RK, Bell MJBayir HFeldman K, Adelson PD, Fink ELKochaneck PMClark RSBCerebrospinal Fluid Levels of High-Mobility Group Box 1 and Cytochrome C Predict Traumatic Outcome after Pediatric Traumatic Brain Injury. J Neuroscience. 2012 Jul 20, 29: 2013-21.

Bonneh-Barkay D, Zagadailov P, Zou H, Niyonkuru C, Figley M, Starkey A, Wang G, Bissel SJ, Wiley CA, Wagner AKYKL-40 expression in traumatic brain injury: an initial analysis. J Neurotrauma. 2010 Jul,27:1215-23.

Drabek THydrogen sulfide-curiouser and curiouser!*. Crit Care Med. 2012 Jul,40:2255-6.

Kline AE, Olsen AS, Sozda CN, Hoffman AN, Cheng JPEvaluation of a Combined Treatment Paradigm Consisting of Environmental Enrichment and the 5-HT(1A) Receptor Agonist Buspirone after Experimental  Traumatic Brain Injury. J Neurotrauma. 2012 Jul 1,29:1960-9. 

Kochanek PM, Bramlett H, Dietrich WD, Dixon CE, Hayes RL, Povlishock J, Tortella FC, Wang KK.  A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy. J Trauma. 2011 Jul,71(1 Suppl):S15-24.

Verrier JD, Jackson TC, Bansal R, Kochanek PM, Puccio AM, Okonkwo DO, Jackson EKThe brain in vivo expresses the 2',3'-cAMP-adenosine pathway. J Neurochem. 2012 Jul,122:115-25.

Sparevero LJ, Amoscato AA, Dixon CE, Long JB, Kochanek PM, Pitt BR, Bayir H, Kagan VE. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. Chem Phys Lipids. 2012 Jul, 165:545-62.

Olsen AS, Sozda CN, Cheng JP, Hoffman AN, Kline AETraumatic Brain Injury-Induced Cognitive and Histological Deficits are Attenuated by Delayed and Chronic Treatment with the 5-HT(1A)-Receptor Agonist Buspirone. J Neurotrauma. 2012 Jul 1, 29:1898-907.

Wagner AK, Hatz LE, Scanlon JM, Niyonkuru C, Miller MA, Ricker JH, Conley YP, Ferrell RE. Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI. Brain Inj. 2012;26(13-14):1658-69


Callaway CW.  Endothelial Damage after Cardiac Arrest-"Endotheliitis".  Resuscitation. 2012 Jun,83:667-8.

Garman RH, Jenkins LW, Switzer RC 3rd, Bauman RA, Tong LC, Swauger PV, Parks SA, Ritzel DV, Dixon CE,Clark RSBayir H, Kagan V, Jackson EKKochanek PMBlast exposure in rats with body shielding is characterized primarily by diffuse axonal injury. J Neurotrauma. 2011 Jun,28:947-59.

Huynh N, Kloke J, Gu C, Callaway CW, Guyette FX, Gebhardt K, Alvarez R, Tisherman SA, Rittenberger JC. The effect of hypothermia "dose" on vasopressor requirements and outcome after cardiac arrest. Resuscitation. 2012 Jun 26. [Epub ahead of print] 

Yelleswarapu NK, Tay JK, Fryer WM, Shah MA, Garcia AN, Cheng JPKline AEElucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.Neuroscience Letters. 2012 May 2, 515(2):153-6.


Dezfulian C, Alekseyenko A, Dave KR, Ravai AP, Do R, Kim F, Perez-Pinzon MA. Nitrite therapy is neuroprotective and safe in cardiac arrest survivors. Nitric Oxide. 2012 May 15, 26:241-50.

Shin SS, Verstynen T, Pathak S, Jarbo K, Hricik AJ, Maserati M, Beers SR, Puccio AM, Boada FE, Okonkwo DO, Schneider W. High-definition fiber tracking for assessment of neurological deficit in a case of traumatic brain injury: finding, visualizing, and interpreting small sites of damage. J Neurosurg. 2012 May,116:1062-9.

Munoz-Price LS, Dezfulian C, Wyckoff M, Lenchus JD, Rosalsky M, Birnbach DJ, Arheart KL. Effectiveness of stepwise interventions targeted to decrease central catheter-associated bloodstream infections. Crit Care Med. 2012 May;40:1464-9.

Russell KC, Arenth PM, Scanlon JM, Kessler L, Ricker JH. Hemispheric and executive influences on low-level language processing after traumatic brain injury. Brain Inj. 2012 May, 26:984-95.

Wagner AK, Brett CA, McCullough EH, Niyonkuru C, Loucks TL, Dixon CE, Ricker J, Arenth P, Berga SL. Persistent hypogonadism influences estradiol synthesis, cognition and outcome in males after severe TBI.  Brain Inj. 2012;26(10):1226-42.


Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RPBell MJ, Adelson PD. Validity of a Pediatric Version of the Glasgow Outcome Scale-Extended. J Neurotrauma. 2012 Apr 10, 29: 1126-39.

Carlson JN, Quintero J, Guyette FX, Callaway CW, Menegazzi JJ. Variables Associated with Successful Intubation Attempts Using Video Laryngoscopy: A Preliminary Report in a Helicopter Emergency Medical Service. Prehosp Emerg Care. 2012 Apr,16,:293-8.

Adelson PD, Pineda J, Bell MJ, Abend NS, Berger RP, Giza CC, Hotz G, Wainwright MS. Common Data Elements for Pediatric Traumatic Brain Injury: Recommendations from the Working Group on Demographics and Clinical Assessment. J Neurotrauma. 2012 Mar 1,29:639-53.

Drabek T, Janata A, Jackson EK, End B, Stezoski JVagni VAJanesko-Feldman K, Wilson CD, van Rooijen N,Tisherman SAKochanek PMMicroglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. Resuscitation. 2012 Apr;83(4):517-26.

Empey PE, Miller TM, Philbrick AH, Melick J, Kochanek PM, Poloyac SM. Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. Crit Care Med. 2012 Apr,40:1221-8.

Drabek T, Janata A, Jackson EK, End B, Stezoski JVagni VAJanesko-Feldman K, Wilson CD, van Rooijen N,Tisherman SAKochanek PMMicroglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. Resuscitation. 2012 Apr,83:517-26.

Fink EL, Panigrahy A, Clark RS, Fitz CR, Landsittel D, Kochanek PM, Zuccoli G. Regional Brain Injury on Conventional and Diffusion Weighted MRI is Associated with Outcome After Pediatric Cardiac Arrest. Neurocrit Care. 2012 Apr 26. [Epub ahead of print] 

Salonia R, Bell MJKochanek PMBerger RPThe Utility of Near Infrared Spectroscopy in Detecting Intracranial Hemorrhage in Children. J Neurotrauma. 2012 Apr 10,29:1047-53.

Shoykhet M, Simons DJ, Alexander H, Holser C, Kochanek PM, Clark RSB. Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats. J Neuroscience. 2012 Apr 4, 32:4972-81.

Tisherman SA.  Rescue therapies in the surgical patient.  Surg Clin North Am. 2012 Apr;92(2):433-9.

Stiell IG, Brown SP, Christenson J, Cheskes S, Nichol G, Powell J, Bigham B, Morrison LJ, Larsen J, Hess E, Vaillancourt C, Davis DP, Callaway CW; the Resuscitation Outcomes Consortium (ROC) Investigators. What is the role of chest compression depth during out-of-hospital cardiac arrest resuscitation? Crit Care Med. 2012 Apr,40:1192-1198.


Berger RP, Beers SR, Papa L, Bell MCommon Data Elements for Pediatric Traumatic Brain Injury: Recommendations from the Biospecimens and Biomarkers Workgroup. J Neurotrauma. 2012 Mar 1,29:672-7.

Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark R, Meaney D, Kochanek PM, Kagan VE, Bayir H.  Mitochondrial Injury after Mechanical Stretch of Cortical Neurons in vitro: Biomarkers of Apoptosis and Selective Peroxidation of Anionic Phospholipids.  J Neurotrauma. 2012 Mar 20;29(5):776-88.

Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark RSB, Meaney DF, Kochanek PM, Kagan VE, Bayir H.Mitochondrial Injury after Mechanical Stretch of Cortical Neurons in vitro: Biomarkers of Apoptosis and Selective Peroxidation of Anionic Phospolipids. J Neurotrauma. 2012 Mar 20,29:776-88.

Manole MDKochanek PM, Foley LM, Hitchens TK, Bayir HAlexander H, Garman R, Ma L, Hsia CJC, HO C, Clark RSB. Polynitroxyl albumin and albumin therapy after pediatric asphyxia cardiac arrest: effects on cerebral blood flow and neurologic outcome. J Cerebral Blood Flow & Metabolism. 2012 Mar, 32:560-9.

Newell E, Bell MJ.  Infections and brain injuries: Beginning to understand the association*.  Pediatr Crit Care Med. 2012 Mar;13(2):222-3.

Shin SS, Bray ER, Dixon CEEffects of Nicotine Administration on Striatal Dopamine Signaling after Traumatic Brain Injury. J  Neurotrauma. 2012 Mar 20,29:843-50.

Tisherman SA.  Spontaneous cooling and rewarming after cardiac arrest may not be therapeutic.  Resuscitation. 2012 Mar;83(3):283-4.

Wagner AK, Zitelli KT. A Rehabilomics focused perspective on molecular mechanisms underlying neurological injury, complications, and recovery after severe TBI. Pathophysiology. 2012 Mar 21. [Epub ahead of print]


Fink ELKochanek PMClark RSBell MJFever control and application of hypothermia using intravenous cold saline. Pediatr Crit Care Med. 2012 Jan,13:80-4.

Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition.  Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, Tong KA, Vavilala MS, Wainwright MS, Warden CR; American Academy of Pediatrics-Section on Neurological Surgery; American Association of Neurological Surgeons/Congress of Neurological Surgeons; Child Neurology Society; European Society of Pediatric and Neonatal Intensive Care; Neurocritical Care Society; Pediatric Neurocritical Care Research Group; Society of Critical Care Medicine; Paediatric Intensive Care Society UK; Society for Neuroscience in Anesthesiology and Critical Care; World Federation of Pediatric Intensive and Critical Care Societies.  Pediatr Crit Care Med. 2012 Jan, 13 Suppl 1:S1-82.

Rittenberger JC, Popescu A, Brenner RP, Guyette FX, Callaway CWFrequency and Timing of Nonconvulsive Status Epilepticus in Comatose Post-Cardiac Arrest Subjects Treated with Hypothermia. Neurocrit Care. 2012 Feb;16(1):114-22.


Machi MS, Staum M, Callaway CW, Moore C, Jeong K, Suyama J, Patterson PD, Hostler D. The Relationship Between Shift Work, Sleep, and Cognition in Career Emergency Physicians. Acad Emerg Med. 2012 Jan, 19:85-91.

Malakouti A, Sookplung P, Siriussawakul A, Philip S, Bailey N, Brown M, Farver K, Zimmerman JJ, Bell MJ, Vavilala MS: Nutrition support and deficiencies in children with severe traumatic brain injury. Pediatr Crit Care Med. 2012 Jan,13:e18-24.

Mills PH, Hitchens TK, Foley LM, Link T, Ye Q, Weiss CR, Thompson JD, Gilson WD, Arepally A, Melick JA,Kochanek PM, Ho C, Bulte JW, Ahrens ET. Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations. Magn Reson Med. 2012 Jan;67(1):278-89.

Patterson PD, Weaver MD, Frank RC, Warner CW, Martin-Gill C, Guyette FX, Fairbanks RJ, Hubble MW, Songer TJ, Callaway CW, Kelsey SF, Hostler D. Association between poor sleep, fatigue, and safety outcomes in emergency medical services providers. Prehosp Emerg Care. 2012 Jan,16:86-97. 

Smith RL, Lin JC, Adelson PD, Kochanek PMFink EL, Wisniewski SR, Bayir H, Tyler-Kabara EC, Clark RS, Brown SD, Bell MJRelationship between hyperglycemia and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med. 2012 Jan,13:85-91.